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QuickView for Snail (gene)


Gene Symbol:
SNAI1 Homo sapiens Homo sapiens
Full name:
snail family transcriptional repressor 1
Synonyms:
SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1, zinc finger protein SNAI1, protein sna, protein snail homolog 1, snail 1 homolog, snail 1 zinc finger protein, snail family zinc finger 1, snail homolog 1
Genomic Location:
Chr 20: 48032934-48038830
Description:
The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least t...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 20
20q13.13


Transcripts Names
NM_005985
Protein Names
O95863
Q9UHH7
Q9P113
Q9UBP7



GO Molecular Function

sequence-specific DNA binding | kinase binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | cation binding | enzyme binding | nucleic acid binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | double-stranded DNA binding | DNA-binding transcription factor activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | metal ion binding | heterocyclic compound binding

GO Biological Process

Notch signaling pathway | molting cycle | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | negative regulation of embryonic development | epidermis morphogenesis | cell motility | developmental process involved in reproduction | regulation of localization | morphogenesis of an epithelium | negative regulation of vitamin D biosynthetic process | regulation of programmed cell death | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | cell differentiation | regulation of vitamin metabolic process | epithelial to mesenchymal transition | left/right pattern formation | epithelial to mesenchymal transition involved in endocardial cushion formation | positive regulation of cellular component movement | mesenchyme development | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | regulation of cell motility | localization | chromatin organization | mesoderm morphogenesis | regulation of DNA damage response, signal transduction by p53 class mediator | heart morphogenesis | negative regulation of signaling | reproductive system development | positive regulation of epithelial to mesenchymal transition | mesoderm development | regulation of embryonic development | negative regulation of nucleic acid-templated transcription | negative regulation of apoptotic process | negative regulation of lipid biosynthetic process | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | negative regulation of apoptotic signaling pathway | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | regulation of bicellular tight junction assembly | epithelium development | cellular component organization | response to stimulus | mesoderm formation | trophoblast giant cell differentiation | roof of mouth development | reproduction | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cartilage development | regulation of cell differentiation involved in embryonic placenta development | regulation of steroid biosynthetic process | embryo development | regulation of steroid metabolic process | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | embryonic placenta development | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | locomotion | endocardial cushion development | heterochromatin organization | system development | reproductive process | regulation of signal transduction | multicellular organism development | cell migration | regulation of intrinsic apoptotic signaling pathway | hair follicle morphogenesis | cardiac epithelial to mesenchymal transition | regulation of gene expression | endocardial cushion morphogenesis | regulation of signal transduction by p53 class mediator | positive regulation of cellular metabolic process | animal organ morphogenesis | regulation of nitrogen compound metabolic process | regulation of cell migration | negative regulation of signal transduction by p53 class mediator | regulation of cellular component movement | regulation of transcription by RNA polymerase II | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | positive regulation of cell differentiation | positive regulation of cell migration | cell differentiation involved in embryonic placenta development | mesenchyme morphogenesis | epidermis development | regulation of apoptotic signaling pathway | skin development | chordate embryonic development | cell communication | regulation of cellular metabolic process | heart development | regulation of locomotion | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | regulation of lipid biosynthetic process | embryonic morphogenesis | DNA-binding transcription factor activity | regionalization | hair cycle | tissue morphogenesis | negative regulation of DNA damage response, signal transduction by p53 class mediator | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | negative regulation of lipid metabolic process | mesenchymal cell differentiation | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | embryonic organ development | hair cycle process | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | regulation of response to DNA damage stimulus | cartilage morphogenesis | connective tissue development | negative regulation of intrinsic apoptotic signaling pathway | regulation of intrinsic apoptotic signaling pathway in response to DNA damage | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | skin epidermis development | anatomical structure formation involved in morphogenesis | negative regulation of cell differentiation involved in embryonic placenta development | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | endocardial cushion formation | anatomical structure morphogenesis | reproductive structure development | regulation of developmental process | developmental process | organelle organization | negative regulation of steroid metabolic process | negative regulation of transcription by RNA polymerase II | regulation of cell junction assembly | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | formation of primary germ layer | regulation of epithelial to mesenchymal transition | in utero embryonic development | regulation of lipid metabolic process | positive regulation of metabolic process | chromosome organization | ossification | osteoblast differentiation | skeletal system development | gastrulation | placenta development | regulation of cell death | positive regulation of cell motility | negative regulation of cell death | circulatory system development | negative regulation of cell differentiation | regulation of cellular component organization | negative regulation of steroid biosynthetic process | hair follicle development | signal transduction | regulation of signaling | Notch signaling involved in heart development | positive regulation of gene expression | multicellular organismal process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | chromosome, centromeric region | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | chromatin | pericentric heterochromatin | membrane-bounded organelle | heterochromatin | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular