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QuickView for Sox2 (gene)


Gene Symbol:
SOX2 Homo sapiens Homo sapiens
Full name:
SRY-box 2
Synonyms:
ANOP3, MCOPS3, transcription factor SOX-2, SRY (sex determining region Y)-box 2, SRY-related HMG-box gene 2, sex determining region Y-box 2, transcription factor SOX2
Genomic Location:
Chr 3: 182912416-182914918
Description:
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations i...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
TGGAAA_NFAT_Q4_01 GATTGGY_NFY_Q6_01 RTAAACA_FREAC2_01 ATAAGCT_MIR21 FREAC7_01 TFIIA_Q6 OCT1_B GATA1_01 ETS_Q4 FOXJ2_02
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 3
3q26.33


Transcripts Names
NM_003106
Protein Names
A0A0U3FYV6
P48431
Q14537



GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | miRNA binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | heterocyclic compound binding | RNA binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | brain development | positive regulation of macromolecule biosynthetic process | regulation of cysteine-type endopeptidase activity | response to cytokine | regulation of neurogenesis | regulation of cell development | somatic stem cell population maintenance | regulation of programmed cell death | eye development | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | cell differentiation | nervous system development | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | generation of neurons | positive regulation of cellular biosynthetic process | cellular process | cell fate specification | chromatin organization | negative regulation of signaling | developmental growth | negative regulation of nucleic acid-templated transcription | stem cell population maintenance | regulation of proteolysis | regulation of cell cycle | response to growth factor | positive regulation of nitrogen compound metabolic process | diencephalon development | regulation of canonical Wnt signaling pathway | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | regeneration | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | gliogenesis | pituitary gland development | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | head development | response to stimulus | positive regulation of protein metabolic process | response to stress | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | positive regulation of cell-cell adhesion | cellular nitrogen compound metabolic process | endodermal cell fate commitment | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | regulation of cell adhesion | cellular biosynthetic process | embryo development | adenohypophysis development | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | regulation of peptidase activity | regulation of MAPK cascade | regulation of catalytic activity | regulation of phosphorylation | wound healing | regulation of neuron differentiation | regulation of gene expression | cell cycle | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | endoderm formation | positive regulation of cell differentiation | cellular response to cytokine stimulus | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | glial cell differentiation | endodermal cell fate specification | endocrine system development | sensory organ development | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | inner ear development | regulation of protein phosphorylation | regulation of RNA metabolic process | embryonic morphogenesis | neuronal stem cell population maintenance | negative regulation of epithelial cell proliferation | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | positive regulation of protein modification process | response to organic substance | gland development | cell cycle arrest | response to wounding | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | metabolic process | cell fate commitment | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | ear development | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | maintenance of cell number | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | forebrain development | negative regulation of neuron differentiation | gene expression | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | transcription, DNA-templated | positive regulation of MAPK cascade | anatomical structure formation involved in morphogenesis | negative regulation of cell cycle | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | glial cell fate commitment | regulation of epithelial cell proliferation | positive regulation of phosphorylation | endodermal cell differentiation | endoderm development | anatomical structure morphogenesis | regulation of endopeptidase activity | cellular macromolecule biosynthetic process | cell fate commitment involved in formation of primary germ layer | regulation of nervous system development | regulation of developmental process | developmental process | negative regulation of canonical Wnt signaling pathway | organelle organization | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | regulation of cell-cell adhesion | positive regulation of nucleic acid-templated transcription | formation of primary germ layer | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | central nervous system development | positive regulation of metabolic process | chromosome organization | negative regulation of Wnt signaling pathway | ossification | osteoblast differentiation | gastrulation | cellular metabolic process | cellular response to organic substance | regulation of cell death | negative regulation of cell development | tissue regeneration | negative regulation of cell differentiation | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

nuclear transcription factor complex | intracellular membrane-bounded organelle | cell | nuclear lumen | transcription factor complex | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular