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QuickView for Srb1 (gene)


Gene Symbol:
SCARB1 Homo sapiens Homo sapiens
Full name:
scavenger receptor class B member 1
Synonyms:
CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1, scavenger receptor class B member 1, CD36 and LIMPII analogous 1, CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1, scavenger receptor class B type III
Genomic Location:
Chr 12: 123828127-123914472
Description:
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Bos taurus Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 12
12q24.31


Transcripts Names
NM_001082959
NM_005505



GO Molecular Function

peptide binding | modified amino acid binding | amyloid-beta binding | protein-containing complex binding | lipid binding | apolipoprotein A-I binding | carbohydrate derivative binding | phospholipid binding | lipoprotein particle binding | anion binding | amide binding | signaling receptor activity | transporter activity | identical protein binding | lipoprotein particle receptor activity | ion binding | signaling pattern recognition receptor activity | low-density lipoprotein particle binding | apolipoprotein binding | high-density lipoprotein particle binding | protein binding | protein homodimerization activity | scavenger receptor activity | phosphatidylserine binding | lipopolysaccharide receptor activity | protein dimerization activity | lipopolysaccharide binding | phosphatidylinositol binding | virus receptor activity | 1-phosphatidylinositol binding | high-density lipoprotein particle receptor activity | cargo receptor activity

GO Biological Process

positive regulation of immune response | high-density lipoprotein particle clearance | positive regulation of locomotion | detection of stimulus | extracellular structure organization | cell motility | immune response-regulating signaling pathway | response to lipopolysaccharide | regulation of localization | lipid transport | establishment of localization | blood vessel endothelial cell migration | regulation of immune system process | lipopolysaccharide transport | epithelial cell migration | positive regulation of cellular component movement | sterol metabolic process | innate immune response-activating signal transduction | positive regulation of cellular biosynthetic process | cellular process | organic substance catabolic process | regulation of cell motility | localization | epithelium migration | cholesterol catabolic process | anion transport | positive regulation of nitric-oxide synthase activity | macromolecule localization | positive regulation of oxidoreductase activity | positive regulation of catalytic activity | endothelial cell proliferation | positive regulation of triglyceride biosynthetic process | interspecies interaction between organisms | positive regulation of cholesterol storage | cell recognition | regulation of immune response | regulation of cellular process | cellular response to lipid | regulation of metabolic process | catabolic process | cellular response to molecule of bacterial origin | organic cyclic compound metabolic process | steroid biosynthetic process | cellular component organization | entry into host cell | viral life cycle | positive regulation of epithelial cell migration | response to stimulus | positive regulation of innate immune response | positive regulation of immune system process | response to stress | regulation of phosphatidylcholine catabolic process | endothelial cell migration | cholesterol import | alcohol metabolic process | positive regulation of lipid biosynthetic process | androgen biosynthetic process | regulation of plasma lipoprotein particle levels | sterol homeostasis | cholesterol homeostasis | activation of innate immune response | organic hydroxy compound transport | androgen metabolic process | response to molecule of bacterial origin | immune response-activating signal transduction | detection of lipopolysaccharide | apoptotic cell clearance | regulation of phagocytosis | cellular biosynthetic process | regulation of triglyceride metabolic process | regulation of lipid storage | positive regulation of monooxygenase activity | locomotion | organic hydroxy compound metabolic process | response to external biotic stimulus | detection of molecule of bacterial origin | alcohol catabolic process | detection of chemical stimulus | pattern recognition receptor signaling pathway | cell migration | hormone biosynthetic process | regulation of catalytic activity | vitamin transport | steroid catabolic process | recognition of apoptotic cell | lipid metabolic process | regulation of hormone levels | adhesion of symbiont to host | wound healing | regulation of nitric-oxide synthase activity | viral entry into host cell | organic substance transport | response to lipid | positive regulation of cellular metabolic process | digestive system process | regulation of phospholipid catabolic process | regulation of nitrogen compound metabolic process | regulation of cell migration | small molecule metabolic process | vitamin transmembrane transport | vesicle-mediated transport | regulation of cellular component movement | positive regulation of lipid storage | regulation of endothelial cell migration | positive regulation of cell migration | intestinal absorption | cell proliferation | biosynthetic process | sterol transport | lipoprotein particle receptor activity | organic anion transport | triglyceride homeostasis | lipid biosynthetic process | cholesterol transport | positive regulation of lipid localization | cholesterol efflux | plasma lipoprotein particle clearance | response to bacterium | cell communication | regulation of cellular metabolic process | regulation of lipid catabolic process | signaling pattern recognition receptor activity | homeostatic process | reverse cholesterol transport | plasma lipoprotein particle remodeling | regulation of locomotion | lipopolysaccharide-mediated signaling pathway | regulation of phospholipid metabolic process | viral process | regulation of lipid biosynthetic process | positive regulation of molecular function | phospholipid transport | positive regulation of triglyceride metabolic process | scavenger receptor activity | activation of immune response | response to organic substance | regulation of innate immune response | lipopolysaccharide receptor activity | epithelial cell proliferation | response to wounding | import into cell | phagocytosis, recognition | cell surface receptor signaling pathway | metabolic process | lipid localization | cholesterol metabolic process | high-density lipoprotein particle remodeling | regulation of vesicle-mediated transport | chemical homeostasis | endocytosis | lipid catabolic process | organic substance metabolic process | virus receptor activity | regulation of phosphate metabolic process | positive regulation of endothelial cell migration | regulation of epithelial cell migration | steroid metabolic process | transmembrane transport | signaling | regulation of oxidoreductase activity | regulation of endocytosis | hormone metabolic process | high-density lipoprotein particle receptor activity | response to biotic stimulus | receptor-mediated endocytosis | detection of biotic stimulus | digestion | acylglycerol homeostasis | regulation of transport | protein-lipid complex remodeling | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | ion transport | cargo receptor activity | immune system process | sterol import | cellular metabolic process | ameboidal-type cell migration | cellular response to organic substance | positive regulation of cell motility | low-density lipoprotein particle clearance | phagocytosis | regulation of triglyceride biosynthetic process | lipid homeostasis | regulation of cellular component organization | response to other organism | signal transduction | carbohydrate derivative transport | cellular response to lipopolysaccharide | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | endocytic vesicle membrane | organelle membrane | cell projection membrane | cytoplasmic vesicle | actin-based cell projection | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | membrane microdomain | cell projection | plasma membrane | membrane raft | vacuole | vesicle | extracellular exosome | lytic vacuole | integral component of plasma membrane | extracellular region | microvillus | membrane-bounded organelle | extracellular vesicle | organelle | vesicle membrane | lysosome | extracellular space | cell periphery | microvillus membrane | plasma membrane raft | intracellular vesicle | cell surface | endocytic vesicle | intracellular | caveola | lysosomal membrane | membrane | cytoplasmic vesicle membrane | intrinsic component of plasma membrane | vacuolar membrane