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QuickView for Src (gene)


Gene Symbol:
SRC Homo sapiens Homo sapiens
Full name:
SRC proto-oncogene, non-receptor tyrosine kinase
Synonyms:
ASV, SRC1, THC6, c-SRC, p60-Src, proto-oncogene tyrosine-protein kinase Src, proto-oncogene c-Src, protooncogene SRC, Rous sarcoma, tyrosine kinase pp60c-src, tyrosine-protein kinase SRC-1, v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Genomic Location:
Chr 20: 35406502-35467235
Description:
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the maligna...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 20
20q11.23





GO Molecular Function

ephrin receptor binding | kinase binding | cofactor binding | cadherin binding | hormone receptor binding | protein kinase binding | enzyme binding | protein-containing complex binding | ribonucleotide binding | nucleotide binding | estrogen receptor binding | signaling receptor binding | carbohydrate derivative binding | catalytic activity | ion channel binding | signaling adaptor activity | protein domain specific binding | ATP binding | protein kinase C binding | ubiquitin-like protein ligase binding | protein binding, bridging | anion binding | adenyl nucleotide binding | purine nucleotide binding | phosphatidylinositol 3-kinase activity | nuclear hormone receptor binding | scaffold protein binding | ion binding | integrin binding | organic cyclic compound binding | molecular adaptor activity | cell adhesion molecule binding | purine ribonucleoside triphosphate binding | phosphoprotein binding | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | tetrapyrrole binding | protein tyrosine kinase activity | protein binding | insulin receptor binding | transcription factor binding | ubiquitin protein ligase binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | connexin binding | transferase activity | SH3/SH2 adaptor activity | non-membrane spanning protein tyrosine kinase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | heme binding | steroid hormone receptor binding | growth factor receptor binding | drug binding | kinase activity | heterocyclic compound binding | protein C-terminus binding | small molecule binding | SH2 domain binding

GO Biological Process

positive regulation of immune response | positive regulation of cyclin-dependent protein serine/threonine kinase activity | response to acidic pH | response to extracellular stimulus | regulation of telomere maintenance via telomerase | regulation of ERK1 and ERK2 cascade | brain development | cell morphogenesis | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of cysteine-type endopeptidase activity | response to virus | heart process | response to nutrient levels | actin filament-based process | response to cytokine | response to interleukin-1 | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | neuron projection morphogenesis | immune response-regulating signaling pathway | response to lipopolysaccharide | developmental process involved in reproduction | regulation of cellular localization | positive regulation of ovarian follicle development | intracellular signal transduction | ovarian follicle development | cellular response to platelet-derived growth factor stimulus | positive regulation of apoptotic process | regulation of localization | mammary gland duct morphogenesis | cellular response to progesterone stimulus | cell-substrate adhesion | actin filament bundle organization | morphogenesis of an epithelium | macroautophagy | gonad development | regulation of carbohydrate metabolic process | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | female gonad development | peptidyl-amino acid modification | negative regulation of cysteine-type endopeptidase activity | phosphatidylinositol metabolic process | actin cytoskeleton organization | establishment of localization | negative regulation of protein homooligomerization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | response to hormone | myeloid cell differentiation | negative regulation of cellular process | integrin-mediated signaling pathway | positive regulation of developmental process | regulation of MAP kinase activity | substrate adhesion-dependent cell spreading | negative regulation of RNA biosynthetic process | positive regulation of lymphocyte activation | bone development | cell differentiation | immune response-activating cell surface receptor signaling pathway | signal complex assembly | negative regulation of adherens junction organization | negative regulation of cell-matrix adhesion | nervous system development | response to drug | lymphocyte costimulation | cell part morphogenesis | positive regulation of gonad development | neurogenesis | bone remodeling | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | regulation of protein oligomerization | peptidyl-tyrosine phosphorylation | regulation of organelle organization | positive regulation of cellular component movement | generation of neurons | positive regulation of protein secretion | response to antibiotic | tissue homeostasis | innate immune response activating cell surface receptor signaling pathway | phospholipid metabolic process | negative regulation of DNA metabolic process | hormone-mediated signaling pathway | negative regulation of proteolysis | regulation of bone remodeling | positive regulation of phosphatidylinositol 3-kinase activity | innate immune response-activating signal transduction | positive regulation of cellular biosynthetic process | cellular process | negative regulation of DNA biosynthetic process | Fc-gamma receptor signaling pathway involved in phagocytosis | regulation of cell motility | localization | cell projection morphogenesis | epithelial tube morphogenesis | tissue remodeling | regulation of mitochondrial membrane potential | negative regulation of signaling | neuron development | reproductive system development | response to progesterone | negative regulation of anoikis | immune system development | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | positive regulation of protein kinase activity | hemostasis | negative regulation of apoptotic process | response to hypoxia | axon guidance | regulation of proteolysis | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | myeloid cell development | response to inorganic substance | regulation of canonical Wnt signaling pathway | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | regulation of binding | gamete generation | interspecies interaction between organisms | anatomical structure homeostasis | negative regulation of apoptotic signaling pathway | response to hydrogen peroxide | regulation of protein kinase B signaling | peptidyl-tyrosine autophosphorylation | regulation of immune response | regulation of cellular process | positive regulation of lamellipodium organization | regulation of apoptotic process | positive regulation of insulin receptor signaling pathway | cellular response to lipid | regulation of metabolic process | catabolic process | regulation of protein complex assembly | cellular response to molecule of bacterial origin | positive regulation of cyclin-dependent protein kinase activity | epidermal growth factor receptor signaling pathway | positive regulation of cellular protein metabolic process | bone resorption | epithelium development | cellular response to organonitrogen compound | ephrin receptor signaling pathway | regulation of mitochondrial depolarization | cellular component organization | entry into host cell | cellular lipid metabolic process | response to transforming growth factor beta | positive regulation of epithelial cell migration | mammary gland morphogenesis | development of primary sexual characteristics | head development | regulation of peptide secretion | positive regulation of protein processing | response to stimulus | female gamete generation | cell morphogenesis involved in neuron differentiation | regulation of cellular protein localization | positive regulation of innate immune response | regulation of peptidyl-tyrosine phosphorylation | positive regulation of immune system process | positive regulation of protein metabolic process | negative regulation of cell adhesion | positive regulation of phosphatidylinositol 3-kinase signaling | cellular response to hypoxia | gland morphogenesis | response to stress | neuron projection guidance | regulation of intracellular steroid hormone receptor signaling pathway | germ cell development | positive regulation of cellular protein localization | ovulation cycle | multicellular organismal homeostasis | tube morphogenesis | response to peptide | positive regulation of cell-cell adhesion | regulation of smooth muscle cell migration | development of primary female sexual characteristics | protein destabilization | supramolecular fiber organization | positive regulation of cell activation | activation of innate immune response | reproduction | positive regulation of cytokine secretion | rhythmic process | positive regulation of proteolysis | response to molecule of bacterial origin | negative regulation of protein oligomerization | positive regulation of T cell activation | immune response-activating signal transduction | cellular response to organic cyclic compound | ERBB signaling pathway | regulation of protein transport | blood circulation | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | regulation of caveolin-mediated endocytosis | hemopoiesis | cellular component assembly | regulation of anoikis | protein modification process | steroid hormone mediated signaling pathway | regulation of ovarian follicle development | regulation of protein processing | regulation of peptide transport | regulation of cell adhesion | regulation of phosphatidylinositol 3-kinase activity | response to pH | macromolecule modification | activation of protein kinase activity | regulation of intracellular transport | leukocyte migration | blood coagulation | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | regulation of membrane potential | leukocyte differentiation | locomotion | response to nitrogen compound | cellular response to hormone stimulus | signaling adaptor activity | regulation of cell projection assembly | response to external biotic stimulus | system development | regulation of cyclin-dependent protein serine/threonine kinase activity | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | positive regulation of organelle organization | regulation of protein stability | regulation of adherens junction organization | adherens junction organization | multicellular organism development | negative regulation of catalytic activity | cell migration | cellular response to peptide hormone stimulus | regulation of peptidase activity | regulation of MAPK cascade | phosphorus metabolic process | positive regulation of organelle assembly | actin filament organization | mammary gland development | positive regulation of smooth muscle cell migration | response to fatty acid | positive regulation of podosome assembly | regulation of telomere maintenance | cellular response to insulin stimulus | positive regulation of protein kinase B signaling | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | regulation of intracellular estrogen receptor signaling pathway | cellular response to oxidative stress | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | transcytosis | negative regulation of peptidase activity | wound healing | Fc-gamma receptor signaling pathway | primary ovarian follicle growth | regulation of T cell activation | positive regulation of cell cycle | regulation of small GTPase mediated signal transduction | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | platelet activation | osteoclast differentiation | regulation of female gonad development | axon development | positive regulation of secretion | response to ketone | cellular response to stress | response to lipid | cellular response to peptide | cell cycle | entry of bacterium into host cell | regulation of protein autophosphorylation | myeloid leukocyte differentiation | organophosphate metabolic process | regulation of membrane depolarization | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of telomerase activity | regulation of lymphocyte activation | progesterone receptor signaling pathway | animal organ morphogenesis | regulation of protein localization to nucleus | cellular response to oxygen levels | positive regulation of integrin activation | regulation of platelet-derived growth factor receptor signaling pathway | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cell-substrate adhesion | enzyme linked receptor protein signaling pathway | regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of cell projection organization | regulation of vascular permeability | positive regulation of intracellular signal transduction | positive regulation of protein complex assembly | response to corticosteroid | cellular response to fluid shear stress | vesicle-mediated transport | regulation of cellular component movement | phosphatidylinositol 3-kinase activity | oogenesis | response to oxidative stress | actin filament bundle assembly | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | axonogenesis | activation of protein kinase B activity | negative regulation of extrinsic apoptotic signaling pathway | response to platelet-derived growth factor | positive regulation of cell migration | cell proliferation | positive regulation of protein localization to nucleus | regulation of cellular protein metabolic process | neurotrophin signaling pathway | negative regulation of cell-substrate adhesion | phosphorylation | actomyosin structure organization | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | cellular protein-containing complex assembly | response to toxic substance | regulation of apoptotic signaling pathway | protein phosphorylation | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | positive regulation of cellular response to insulin stimulus | autophagy | cellular response to angiotensin | ovulation cycle process | cellular response to drug | lipid phosphorylation | regulation of telomere maintenance via telomere lengthening | response to bacterium | regulation of lipid kinase activity | angiotensin-activated signaling pathway | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | transmembrane receptor protein serine/threonine kinase signaling pathway | positive regulation of DNA biosynthetic process | contractile actin filament bundle assembly | regulation of protein metabolic process | positive regulation of signal transduction | lipid modification | homeostatic process | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | glycerolipid metabolic process | regulation of RNA metabolic process | positive regulation of transport | regulation of phospholipid metabolic process | viral process | negative regulation of telomere maintenance | cellular response to fatty acid | coagulation | positive regulation of lamellipodium morphogenesis | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | positive regulation of female gonad development | protein tyrosine kinase activity | positive regulation of molecular function | cellular response to transforming growth factor beta stimulus | regulation of cytokine secretion | response to angiotensin | neuron differentiation | multicellular organism reproduction | negative regulation of mitochondrial depolarization | protein-containing complex assembly | regulation of podosome assembly | activation of immune response | regulation of protein homooligomerization | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | gland development | regulation of innate immune response | neurotrophin TRK receptor signaling pathway | tissue morphogenesis | branching morphogenesis of an epithelial tube | regulation of kinase activity | response to wounding | response to mechanical stimulus | import into cell | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | regulation of focal adhesion assembly | response to insulin | anatomical structure development | cell surface receptor signaling pathway | positive regulation of small GTPase mediated signal transduction | regulation of glucose metabolic process | cell projection organization | metabolic process | positive regulation of platelet-derived growth factor receptor signaling pathway | positive regulation of glucose metabolic process | response to mineralocorticoid | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | regulation of body fluid levels | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | regulation of bone resorption | regulation of tissue remodeling | regulation of vesicle-mediated transport | chemical homeostasis | endocytosis | regulation of secretion | positive regulation of cell death | cell adhesion | G-protein coupled receptor signaling pathway involved in heart process | protein kinase activity | cellular response to reactive oxygen species | neuron projection development | negative regulation of protein complex assembly | positive regulation of cellular component biogenesis | organic substance metabolic process | negative regulation of intrinsic apoptotic signaling pathway | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | response to reactive oxygen species | forebrain development | regulation of insulin receptor signaling pathway | negative regulation of cellular protein metabolic process | regulation of cell activation | regulation of protein secretion | negative regulation of telomere maintenance via telomerase | positive regulation of ERK1 and ERK2 cascade | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of integrin activation | ion homeostasis | regulation of cellular response to insulin stimulus | regulation of Wnt signaling pathway | osteoclast development | regulation of phosphate metabolic process | cytoskeleton organization | SH3/SH2 adaptor activity | regulation of chromosome organization | mammary gland epithelium development | cellular response to steroid hormone stimulus | cell-cell adhesion | positive regulation of cytokine production | cell activation | positive regulation of MAPK cascade | intracellular receptor signaling pathway | morphogenesis of a branching epithelium | positive regulation of protein transport | positive regulation of canonical Wnt signaling pathway | transforming growth factor beta receptor signaling pathway | uterus development | negative regulation of protein metabolic process | regulation of epithelial cell migration | positive regulation of carbohydrate metabolic process | T cell costimulation | response to fluid shear stress | non-membrane spanning protein tyrosine kinase activity | regulation of cell communication | positive regulation of protein maturation | negative regulation of chromosome organization | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | regulation of protein binding | response to organic cyclic compound | negative regulation of telomere maintenance via telomere lengthening | cell development | regulation of endocytosis | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | phosphatidylinositol phosphorylation | morphogenesis of a branching structure | anatomical structure morphogenesis | regulation of endopeptidase activity | positive regulation of MAP kinase activity | stress fiber assembly | response to biotic stimulus | reproductive structure development | regulation of developmental process | glycerophospholipid metabolic process | positive regulation of DNA metabolic process | kinase activity | developmental process | organelle organization | regulation of DNA biosynthetic process | Fc receptor signaling pathway | peptidyl-serine phosphorylation | intracellular steroid hormone receptor signaling pathway | cellular protein modification process | negative regulation of focal adhesion assembly | positive regulation of protein autophosphorylation | vascular endothelial growth factor receptor signaling pathway | Fc receptor mediated stimulatory signaling pathway | tube development | regulation of cell junction assembly | regulation of transport | positive regulation of transcription, DNA-templated | regulation of cell-cell adhesion | positive regulation of nucleic acid-templated transcription | regulation of lamellipodium morphogenesis | positive regulation of lipid kinase activity | response to organonitrogen compound | stimulatory C-type lectin receptor signaling pathway | response to electrical stimulus | negative regulation of hydrolase activity | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | regulation of cell projection organization | skeletal system development | immune system process | positive regulation of Wnt signaling pathway | cellular metabolic process | hematopoietic or lymphoid organ development | female sex differentiation | cellular response to organic substance | regulation of protein localization | regulation of cell death | sex differentiation | positive regulation of cell motility | response to steroid hormone | regulation of organelle assembly | negative regulation of cell death | regulation of early endosome to late endosome transport | branching involved in mammary gland duct morphogenesis | chemotaxis | sexual reproduction | phagocytosis | positive regulation of leukocyte cell-cell adhesion | negative regulation of telomerase activity | regulation of cellular component organization | response to other organism | positive regulation of signaling | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | negative regulation of endopeptidase activity | angiotensin-activated signaling pathway involved in heart process | positive regulation of gene expression | regulation of cell-matrix adhesion | cellular response to growth factor stimulus | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

supramolecular fiber | cytoplasmic side of plasma membrane | organelle inner membrane | intracellular membrane-bounded organelle | synapse | mitochondrial inner membrane | late endosome | neuron projection | extrinsic component of membrane | ruffle | organelle membrane | cell projection membrane | cytoplasmic vesicle | cell | cytoplasmic side of membrane | extrinsic component of plasma membrane | ruffle membrane | cytoplasm | intracellular organelle | actin cytoskeleton | membrane microdomain | leading edge membrane | protein-containing complex | cell projection | endomembrane system | postsynapse | plasma membrane | extrinsic component of cytoplasmic side of plasma membrane | cell leading edge | membrane raft | vacuole | vesicle | podosome | perinuclear region of cytoplasm | postsynaptic density | extracellular exosome | asymmetric synapse | mitochondrion | lytic vacuole | endosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | postsynaptic specialization | mitochondrial envelope | lysosome | extracellular space | cell periphery | plasma membrane raft | mitochondrial membrane | cytosol | intracellular vesicle | actin filament | cytoskeleton | intracellular | caveola | membrane | supramolecular complex