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QuickView for Streptomycin (compound)

Name: Streptomycin
PubChem Compound ID: 19648
Description: An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.
Molecular formula: C42H84N14O36S3
Molecular weight: 1457.39 g/mol
Plantomycin; Vetstrep; Ambistryn S; Bis-(4-O-(2-O-(2-desoxy-2-methylamino-alpha-L-glucopyranosyl)-alpha-L-streptosyl)-L-streptidin)-trisulfat; Streptomycin sulfate [USAN:JAN]; Agristrep; Streotitgebat; Strepvet; Streptomycin A sulfate; Streoikub.
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Name: Streptomycin
Name (isomeric): DB01082
Drug Type: small molecule
Description: An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.
Streptomycin a Sulfate; Streptomycin, Sulfate Salt; Streptomycin Sesquisulfate Hydrate; Streptomycin Sulfate; Streptomycin Sulphate
Brand: Kantrex
Brand name mixture:
Poly Vita Pen Strep(Calcium D-Pantothenate + Menadione Sodium Bisulfite + Nicotinic Acid + Penicillin G Procaine + Streptomycin (Streptomycin Sulfate) + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D3 + Vitamin E), Combiotic Vitamin Booster Pws(Calcium D-Pantothenate + Menadione + Nicotinic Acid + Penicillin G Potassium + Pyridoxine Hydrochlor...
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Category: Protein Synthesis Inhibitors, Anti-Bacterial Agents, Aminoglycosides
CAS number: 57-92-1
Indication: For the treatment of tuberculosis. May also be used in combination with other drugs to treat tularemia (Francisella tularensis), plague (Yersia pestis), severe M. avium complex, brucellosis, and enterococcal endocarditis (e.g. E. faecalis, E. faecium).
Streptomycin is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, ...
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Mechanism of Action:
Aminoglycosides like Streptomycin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Streptomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in t...
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Absorption: Rapidly absorbed after intramuscular injection with peak serum concentrations attained after 1 - 2 hours. Not absorbed in the GI tract.
Route of elimination: Small amounts are excreted in milk, saliva, and sweat. Streptomycin is excreted by glomerular filtration.
Half Life: 5 - 6 hours in adults with normal renal function
Toxicity: Nephrotoxic and ototoxic potential. Nephrotoxicity is caused by accumulation of the drug in proximal renal tubular cells, which results in cellular damage. Tubular cells may regenerate despite continued exposure and nephrotoxicity is usually mild and reversible. Streptomycin is the least nephrotoxic of the aminoglycosides owing to the small number of cationic amino groups in its structure. Otoxocity occurs via drug accumulation in the endolymph and perilymph of the inner ear. Accumulation causes irreversible damage to hair cells of the cochlea or summit of the ampullar cristae of the vestibular complex. High frequency hearing loss precedes low frequency hearing loss. Further toxicity may result in retrograde degeneration of the auditory nerve. Vestibular toxicity may result in vertigo, nausea and vomiting, dizziness and loss of balance. LD50=430 mg/kg (Orally in rats with Streptomycin Sulfate); Side effects include nausea, vomiting, and vertigo, paresthesia of face, rash, fever, urticaria, angioneurotic edema, and eosinophilia.
Affected organisms: Enteric bacteria and other eubacteria
Drug interaction:
CefoxitinIncreased risk of nephrotoxicity
CefotetanIncreased risk of nephrotoxicity
FurosemideIncreased ototoxicity
Ethacrynic acidIncreased ototoxicity
TicarcillinTicarcillin may reduce the serum concentration of Streptomycin. Ticarcillin may inactivate Streptomycin in vitro and the two agents should not be administered simultaneously through the same IV line.
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