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QuickView for Streptomycin (compound)

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PubChem

PubChem Compound 19648

PubChem Compound 19648

Name:	Streptomycin
PubChem Compound ID:	19648
Description:	An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.
Molecular formula:	C₄₂H₈₄N₁₄O₃₆S₃
Molecular weight:	1457.39 g/mol
Synonyms:	Plantomycin; Vetstrep; Ambistryn S; Bis-(4-O-(2-O-(2-desoxy-2-methylamino-alpha-L-glucopyranosyl)-alpha-L-streptosyl)-L-streptidin)-trisulfat; Streptomycin sulfate [USAN:JAN]; Agristrep; Streotitgebat; Strepvet; Streptomycin A sulfate; Streoikub. show more » Plantomycin; Vetstrep; Ambistryn S; Bis-(4-O-(2-O-(2-desoxy-2-methylamino-alpha-L-glucopyranosyl)-alpha-L-streptosyl)-L-streptidin)-trisulfat; Streptomycin sulfate [USAN:JAN]; Agristrep; Streotitgebat; Strepvet; Streptomycin A sulfate; Streoikub; Streptomycin, sulfate (2:3) (salt); DRG-0201; 57-92-1; EPA Pesticide Chemical Code 006310; Estreptomicina; Streptomycin sulfate (2:3) (salt); 298-39-5; Caswell No. 804A; Streptomycin sulphate B.P; Strycin; EINECS 223-286-0; 3810-74-0; Agri-Strep; Streptomycin sesquisulfate; 67479-32-7; Intromycin; Streptomycin sulfate (2:3); Strepsulfat; 15105-93-8; 85027-84-5; Phytomycin; NSC 14083; AS-15; Agrimycin 17; AI3-50158; Strepcin; Streptomycin sulphate; Streptorex; Estreptopanto; CCRIS 5934; D-Streptamine, O-2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl-(1-4)-N,N'-bis(aminoiminomethyl)-, sulfate (2:3) (salt); 8018-05-1; Streptomycin sulfate; Streptomycinium sulfuricum; STREPTOMYCIN SULFATE (2:3) SALT; Streptomyzinsulfat; Strep-gran show less «

DrugBank

Identification

Name:	Streptomycin
Name (isomeric):	DB01082
Drug Type:	small molecule
Description:	An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.
Synonyms:	Streptomycin a Sulfate; Streptomycin, Sulfate Salt; Streptomycin Sesquisulfate Hydrate; Streptomycin Sulfate; Streptomycin Sulphate
Brand:	Kantrex
Brand name mixture:	Poly Vita Pen Strep(Calcium D-Pantothenate + Menadione Sodium Bisulfite + Nicotinic Acid + Penicillin G Procaine + Streptomycin (Streptomycin Sulfate) + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D3 + Vitamin E), Combiotic Vitamin Booster Pws(Calcium D-Pantothenate + Menadione + Nicotinic Acid + Penicillin G Potassium + Pyridoxine Hydrochlor... show more » Poly Vita Pen Strep(Calcium D-Pantothenate + Menadione Sodium Bisulfite + Nicotinic Acid + Penicillin G Procaine + Streptomycin (Streptomycin Sulfate) + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D3 + Vitamin E), Combiotic Vitamin Booster Pws(Calcium D-Pantothenate + Menadione + Nicotinic Acid + Penicillin G Potassium + Pyridoxine Hydrochloride + Streptomycin (Streptomycin Sulfate) + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D3 + Vitamin E), Medic Aid 2-50(Menadione Sodium Bisulfite + Penicillin (Penicillin G Potassium) + Penicillin (Penicillin G Procaine) + Streptomycin Sulfate + Vitamin a + Vitamin D3), Previte(Neomycin (Neomycin Sulfate) + Selenium (Selenium Sulfide) + Streptomycin (Streptomycin Sulfate) + Vitamin a + Vitamin D + Vitamin E + Vitamin K1), Poultry Rx Pwr(Calcium D-Pantothenate + Folic Acid + Menadione Sodium Bisulfite + Nicotinic Acid + Penicillin G Potassium + Streptomycin (Streptomycin Sulfate) + Vitamin a + Vitamin B1 + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin D3 + Vitamin E), Mastitis Care(Neomycin (Neomycin Sulfate) + Penicillin G Potassium + Polymyxin B (Polymyxin B Sulfate) + Streptomycin (Streptomycin Sulfate)), Poly Tonine a Super Booster No.1(Calcium D-Pantothenate + Menadione + Nicotinamide + Penicillin G Potassium + Pyridoxine Hydrochloride + Streptomycin Sulfate + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D3 + Vitamin E (Dl-Alpha Tocopheryl Acetate)), Sulectim Plus Scour Boluses(Calcium Carbonate + Magnesium Oxide + Menadione Sodium Bisulfite + Neomycin (Neomycin Sulfate) + Potassium Acetate + Sodium Acetate + Sodium Chloride + Streptomycin (Streptomycin Sulfate) + Sulfamerazine + Sulfamethazine + Sulfanilamide + Sulfathiazole Sodium + Vitamin a + Vitamin D), P.T. Booster(Calcium D-Pantothenate + Neomycin (Neomycin Sulfate) + Nicotinic Acid + Pyridoxine Hydrochloride + Streptomycin (Streptomycin Sulfate) + Vitamin a + Vitamin B1 + Vitamin B12 + Vitamin B2 + Vitamin D3), Medivit(Calcium D-Pantothenate + Menadione + Nicotinamide + Penicillin G Potassium + Pyridoxine Hydrochloride + Streptomycin Sulfate + Vitamin a + Vitamin B1 + Vitamin B12 + Vitamin B2 + Vitamin D3 + Vitamin E), Sul Dyo Strep(Aluminum Hydroxide + Kaolin + Pectin + Streptomycin Sulfate + Sulfamethazine), Pig Booster Liq Coop(Calcium D-Pantothenate + Neomycin + Nicotinic Acid + Streptomycin + Vitamin a + Vitamin B1 + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin D), Aurex Rotenone Drops(Bacitracin + Penicillin + Rotenone + Streptomycin (Streptomycin Sulfate) + Undecylenic Acid), Scour Bolus Plus(Calcium Carbonate + Magnesium Oxide + Menadione (Menadione Sodium Bisulfite) + Neomycin (Neomycin Sulfate) + Potassium Acetate + Sodium Acetate + Sodium Chloride + Streptomycin (Streptomycin Sulfate) + Sulfamerazine + Sulfamethazine + Sulfanilamide + Sulfathiazole + Vitamin a + Vitamin D), Neospan Mastitis Treatment(Neomycin (Neomycin Sulfate) + Penicillin G Potassium + Polymyxin B (Polymyxin B Sulfate) + Streptomycin (Streptomycin Sulfate)), Vibiomed Fmx(Calcium D-Pantothenate + Dl-Alpha Tocopheryl Acetate + Menadione + Nicotinamide + Penicillin G Potassium + Pyridoxine Hydrochloride + Streptomycin Sulfate + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D3), Pig Zest(Calcium D-Pantothenate + Neomycin (Neomycin Sulfate) + Nicotinic Acid + Pyridoxine Hydrochloride + Streptomycin (Streptomycin Sulfate) + Vitamin a + Vitamin B1 + Vitamin B12 + Vitamin B2 + Vitamin D3), Polytonine a Super Booster No 1 Pws(Calcium D-Pantothenate + Menadione + Nicotinamide + Penicillin G Potassium + Pyridoxine Hydrochloride + Streptomycin (Streptomycin Sulfate) + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D3 + Vitamin E (Dl-Alpha Tocopheryl Acetate)), Parvit Plus(Penicillin G Procaine + Streptomycin Sulfate + Vitamin a + Vitamin C + Vitamin D3 + Vitamin E + Vitamin K1), Stimu-Pig(Calcium D-Pantothenate + Neomycin (Neomycin Sulfate) + Nicotinic Acid + Pyridoxine Hydrochloride + Streptomycin (Streptomycin Sulfate) + Vitamin a + Vitamin B1 + Vitamin B12 + Vitamin B2 + Vitamin D3), Pig Starter Liq(Calcium D-Pantothenate + Neomycin Sulfate + Nicotinic Acid + Pyridoxine Hydrochloride + Streptomycin Sulfate + Vitamin a + Vitamin B1 + Vitamin B12 + Vitamin B2 + Vitamin D), Dp Booster Pws(D-Pantothenic Acid (Calcium D-Pantothenate) + Menadione + Nicotinic Acid + Penicillin G Potassium + Pyridoxine Hydrochloride + Streptomycin (Streptomycin Sulfate) + Vitamin a + Vitamin B1 + Vitamin B12 + Vitamin B2 + Vitamin D3 + Vitamin E), Streptocilline - Sp Pws(Calcium D-Pantothenate + Menadione + Nicotinamide + Penicillin G Potassium + Pyridoxine Hydrochloride + Streptomycin Sulfate + Thiamine Hydrochloride + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D3 + Vitamin E) show less «
Category:	Protein Synthesis Inhibitors, Anti-Bacterial Agents, Aminoglycosides
CAS number:	57-92-1

Pharmacology

Indication:	For the treatment of tuberculosis. May also be used in combination with other drugs to treat tularemia (Francisella tularensis), plague (Yersia pestis), severe M. avium complex, brucellosis, and enterococcal endocarditis (e.g. E. faecalis, E. faecium).
Pharmacology:	Streptomycin is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, ... show more » Streptomycin is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses. show less «
Mechanism of Action:	Aminoglycosides like Streptomycin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Streptomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in t... show more » Aminoglycosides like Streptomycin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Streptomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes. show less «
Absorption:	Rapidly absorbed after intramuscular injection with peak serum concentrations attained after 1 - 2 hours. Not absorbed in the GI tract.
Route of elimination:	Small amounts are excreted in milk, saliva, and sweat. Streptomycin is excreted by glomerular filtration.
Half Life:	5 - 6 hours in adults with normal renal function
Toxicity:	Nephrotoxic and ototoxic potential. Nephrotoxicity is caused by accumulation of the drug in proximal renal tubular cells, which results in cellular damage. Tubular cells may regenerate despite continued exposure and nephrotoxicity is usually mild and reversible. Streptomycin is the least nephrotoxic of the aminoglycosides owing to the small number of cationic amino groups in its structure. Otoxocity occurs via drug accumulation in the endolymph and perilymph of the inner ear. Accumulation causes irreversible damage to hair cells of the cochlea or summit of the ampullar cristae of the vestibular complex. High frequency hearing loss precedes low frequency hearing loss. Further toxicity may result in retrograde degeneration of the auditory nerve. Vestibular toxicity may result in vertigo, nausea and vomiting, dizziness and loss of balance. LD50=430 mg/kg (Orally in rats with Streptomycin Sulfate); Side effects include nausea, vomiting, and vertigo, paresthesia of face, rash, fever, urticaria, angioneurotic edema, and eosinophilia.
Affected organisms:	Enteric bacteria and other eubacteria

Interactions

Drug interaction:

Cefoxitin	Increased risk of nephrotoxicity
Cefotetan	Increased risk of nephrotoxicity
Furosemide	Increased ototoxicity
Ethacrynic acid	Increased ototoxicity
Ticarcillin	Ticarcillin may reduce the serum concentration of Streptomycin. Ticarcillin may inactivate Streptomycin in vitro and the two agents should not be administered simultaneously through the same IV line.

Targets

30S ribosomal protein S12

Transporters

Solute carrier family 22 member 6