Bookmark
Forward
QuickView for Succinylcholine (compound)
PubChem
| Name: | Succinylcholine |
|---|---|
| PubChem Compound ID: | 22475 |
| Description: | A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for. |
| Molecular formula: | C14H30Cl2N2O4 |
| Molecular weight: | 361.304 g/mol |
| Synonyms: |
Succamethonium chloratum; 2-Dimethylaminoethyl succinate dimethochloride; Succinylcholine chloride [USAN]; Suxamethonii chloridum; Anectine (TN); AI3-51679; NSC 49132; Anectine; Succicuran; Pantolax.
show more » |
DrugBank
Identification
| Name: | Succinylcholine |
|---|---|
| Name (isomeric): | DB00202 |
| Drug Type: | small molecule |
| Description: | A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for. |
| Synonyms: |
Scoline; Succinylcholine Chloride; Suxamethonium chloride
|
| Brand: | Sucostrin, Quelicin, Anectine, Quelicin Preservative Free |
| Category: | Neuromuscular Depolarizing Agents, Skeletal Muscle Relaxants |
| CAS number: | 306-40-1 |
Pharmacology
| Indication: | Used in surgical procedures where a rapid onset and brief duration of muscle relaxation is needed (includes intubation, endoscopies, and ECT) |
|---|---|
| Pharmacology: |
Succinylcholine is indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Succinylcholine is a depolarizing skeletal muscle relaxant. As does acetylcholine, it combines with the cholinergic receptors of the motor end plate to produce depol...
show more » |
| Mechanism of Action: | The mechanism of action of Succinylcholine involves what appears to be a "persistent" depolarization of the neuromuscular junction. This depolarization is caused by Succinylcholine mimicking the effect of acetylcholine but without being rapidly hydrolysed by acetylcholinesterase. This depolarization leads to desensitization. |
| Biotransformation: | By pseudocholinesterase, to succinylmonocholine and choline. |
| Route of elimination: | About 10% of the drug is excreted unchanged in the urine. |
| Affected organisms: | Humans and other mammals |
Interactions
| Drug interaction: |
|
|---|
Targets
Enzymes
