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QuickView for Sufentanil (compound)


PubChem
Name: Sufentanil
PubChem Compound ID: 41693
Description: An opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent.
Molecular formula: C22H30N2O2S
Molecular weight: 386.552 g/mol
Synonyms:
Propanamide, N-[4-(methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidinyl]-N-phenyl-; Propanamide, N-(4-(methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidinyl)-N-phenyl-; N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidyl)propionanilide; 60561-17-3; Chronogesic; Sufentanil [USAN:BAN:INN]; HSDB 6760; R 30730; C08022; N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidinyl)-N-phenylpropanamide.
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DrugBank
Identification
Name: Sufentanil
Name (isomeric): DB00708
Drug Type: small molecule
Description: An opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent.
Synonyms:
Sulfentanil Citrate; Sufentanil Citrate; Sufentanyl; Sufentanilum [INN-Latin]
Brand: Chronogesic, Sufenta
Category: Anesthetics, Intravenous, Adjuvants, Anesthesia, Narcotics, Opiate Agonists, Analgesics, Opioid
CAS number: 56030-54-7
Pharmacology
Indication: Used as an analgesic adjunct in anesthesia and as a primary anesthetic drug in procedures requiring assisted ventilation and in the relief of pain.
Pharmacology:
Sufentanil is a synthetic opioid analgesic. Sufentanil interacts predominately with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, spinal cord, and other tissues. In clinical settings, sufentanil exerts its principal pharmacologic effects on the central nervous system. Its primary actions of therapeuti...
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Mechanism of Action:
Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface ...
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Half Life: 265 minutes
Toxicity: LD50: 18.7 mg/kg (IV in mice)
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
CimetidineIncreases the effect of the narcotic
TriprolidineThe CNS depressants, Triprolidine and Sufentanil, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
VoriconazoleVoriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of sufentanil by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of sufentanil if voriconazole is initiated, discontinued or dose changed.
TranylcyprominePossible increased risk of serotonin syndrome.
TelithromycinTelithromycin may reduce clearance of Sufentanil. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Sufentanil if Telithromycin is initiated, discontinued or dose changed.

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