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QuickView for Sulfadoxine (compound)
PubChem
| Name: | Sulfadoxine |
|---|---|
| PubChem Compound ID: | 17134 |
| Description: | A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections. |
| Molecular formula: | C12H14N4O4S |
| Molecular weight: | 310.33 g/mol |
| Synonyms: |
N'-(5,6-Dimethoxy-4-pyrimidyl)sulfanilamide; EINECS 219-504-9; WR 4873; Sanasil: Sulfadoxine: Sulformetoxin; Sulphadoxine; NCGC00016612-01; 5-25-13-00306 (Beilstein Handbook Reference); AIDS-007816; Prestwick0_001094; Prestwick1_001094.
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DrugBank
Identification
| Name: | Sulfadoxine |
|---|---|
| Name (isomeric): | DB01299 |
| Drug Type: | small molecule |
| Description: | A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections. |
| Category: | Antimalarials, Anti-Infective Agents, Anti-Infective Agents, Urinary |
| CAS number: | 2447-57-6 |
Pharmacology
| Indication: | Sulfadoxine is used in combination with pyrimethamine for the treatment or prevention of malaria. It can also be used to treat various infections in livestock as well. Sulfadoxine and pyrimethamine is indicated for the treatment of Plasmodium falciparum malaria in those patients in whom chloroquine resistance is suspected. |
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| Pharmacology: | Sulfadoxine helps inhibit the enzyme dihydropteroate synthetase which is an enzyme necessary in the conversion of PABA to folic acid. As folic acid is vital to the synthesis, repair, and methylation of DNA which is vital to cell growth in Plasmodium falciparum. With this vital nutrient lacking, the parasite has difficulty in reproducing. |
| Mechanism of Action: |
Sulfadoxine is a sulfa drug, often used in combination with pyrimethamine to treat malaria. This medicine may also be used to prevent malaria in people who are living in, or will be traveling to, an area where there is a chance of getting malaria. Sulfadoxine targets Plasmodium dihydropteroate synthase and dihydrofolate reductase. Sulfa drugs or ...
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Interactions
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Targets
