Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward

QuickView for Sulfamerazine (compound)


PubChem
Name: Sulfamerazine
PubChem Compound ID: 5325
Description: A sulfanilamide that is used as an antibacterial agent.
Molecular formula: C11H12N4O2S
Molecular weight: 264.305 g/mol
Synonyms:
Spectrum_000003; Romezin; Sulfamethyldiazine; SPBio_001419; EINECS 204-866-2; AIDS-008282; Kelamerazine; Sulfanilamide, N1-(4-methyl-2-pyrimidinyl)- (8CI); Prestwick0_000694; Cremomerazine.
show more »
DrugBank
Identification
Name: Sulfamerazine
Name (isomeric): DB01581
Drug Type: small molecule
Description: A sulfanilamide that is used as an antibacterial agent.
Category: Anti-Infective Agents, Sulfonamides
CAS number: 127-79-7
Pharmacology
Indication: A sulfanilamide that is used as an antibacterial agent. It can be used to treat bronchitis, prostatitis and urinary tract infections.
Pharmacology: Sulfonamides act as competitive inhibitors of the enzyme dihydropteroate synthetase (DHPS), an enzyme involved in folate synthesis in bacteria.
Mechanism of Action:
Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthetase (dihydrofolate synthetase). Sulfamerazine is bacteriostatic in nature. Inhibition of dihydrofolic acid synthesis decreases the synthesis of bacterial nucleotides and DNA...
show more »
Absorption: Rapidly absorbed following oral administration.
Toxicity: Sulfamerazine may cause nausea, vomiting, diarrhea and hypersensitivity reactions. Hematologic effects such as anemia, agranulocytosis, thrombocytopenia and hemolytic anemia in patients with glucose-6-phosphate dehydrogenase deficiency may also occur. Sulfamethoxazole may displace bilirubin from albumin binding sites causing jaundice or kernicterus in newborns.
Interactions
Food interaction:
Do not take calcium, aluminium, magnesium or iron supplements within 2 hours of taking this medication.
Drug interaction:
ChlorpropamideSulfonamide/sulfonylurea: possible hypoglycemia
MethotrexateThe sulfamide increases the toxicity of methotrexate

Targets


Carriers