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QuickView for Sulfisoxazole (compound)
PubChem
| Name: | Sulfisoxazole |
|---|---|
| PubChem Compound ID: | 10996285 |
| Description: | A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. |
| Molecular formula: | C53H80O2 |
| Molecular weight: | 750.194 g/mol |
DrugBank
Identification
| Name: | Sulfisoxazole |
|---|---|
| Name (isomeric): | DB00263 |
| Drug Type: | small molecule |
| Description: | A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. |
| Synonyms: |
Sulfofurazole; Sulphaisoxazole; Sulphafurazol; Sulfisoxazole Dialamine; Sulfaisoxazole; Sulfisoxazole Diolamine; Sulphofurazole; Sulfisoxasole; Sulfasoxazole; Sulfafurazole.
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| Brand: | Norilgan-S, Saxosozine, Dorsulfan, Soxamide, Roxoxol, Astrazolo, Sulsoxin, Entusul, Tl-Azole, Amidoxal, Unisulf, Sulfasan, Entusil, Stansin, Bactesulf, Sulfagen, Neoxazol, Novazolo, Soxisol, Sulfoxol, Azo Gantrisin, Renosulfan, J-Sul, Sulfagan, Resoxol, Gantrisona, Roxosul Tablets, G-Sox, Sulfapolar, Sodizole, Sulbio, Isoxamin, Soxazole, Dorsulfan Warthausen, Sulfisin, Gantrisin, Suloxsol, Sulfazin, Thiasin, Chemouag, Sulphafuraz, Sulfizol, Barazae, Roxosul, Sulfizole, Novosaxazole, Koro-Sulf, Gantrosan, Azosulfizin, Soxomide, Uritrisin, Soxitabs, Soxo, Neazolin, Sulfizin, Sulfasol, Sosol, SI, V-Sul, Sulfalar, Ganda, Cosoxazole, Sk-Soxazole, Accuzole, Pancid, Alphazole, Vagilia, Gantrisine, Urogan, Urisoxin |
| Brand name mixture: | Renazone Plus Tab(Ammonium Chloride + Atropine Sulfate + Hyoscyamine Hydrobromide + Scopolamine Hydrobromide + Sulfisoxazole), Pediazole(Erythromycin (Erythromycin Ethylsuccinate) + Sulfisoxazole Acetyl) |
| Category: | Anti-Infective Agents, Sulfonamides, Anti-Infectives |
| CAS number: | 127-69-5 |
Pharmacology
| Indication: | For the treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections. |
|---|---|
| Pharmacology: |
Sulfisoxazole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminob...
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| Mechanism of Action: |
Sulfisoxazole is a competitive inhibitor of the enzyme dihydropteroate synthetase. It inhibits bacterial synthesis of dihydrofolic acid by preventing the condensation of the pteridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of ...
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| Route of elimination: | The mean urinary excretion recovery following oral administration of sulfisoxazole is 97% within 48 hours, of which 52% is intact drug, with the remaining as the N4-acetylated metabolite. It is excreted in human milk. |
| Toxicity: | LD50=6800 mg/kg (Orally in mice) |
| Affected organisms: | Enteric bacteria and other eubacteria |
Interactions
| Drug interaction: |
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Targets
Enzymes
