Bookmark
Forward
QuickView for Suramin (compound)
PubChem
| Name: | Suramin |
|---|---|
| PubChem Compound ID: | 5361 |
| Description: | A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties. |
| Molecular formula: | C51H40N6O23S6 |
| Molecular weight: | 1297.29 g/mol |
| Synonyms: |
NSC34936; Naganil; sym-bis(m-aminobenzoyl-m-amino-p-methylbenzoyl-1-napthylamino-4,6,8-trisulfonate) carbamide; Naganin; 1,3,5-Naphthylenetrisulfonic acid, 8,8'-(ureylenebis(m-phenylenecarbonylimino(4-methyl-m-phenylene)carbonylimino))di-; Carbanilide, 3,3'-bis((5-((4,6,8-trisulfo-1-naphthyl)carbamoyl)-o-tolyl)carbamoyl)-; Harnstoff, symmetischer der 3-aminobenzoyl-3-amino-4-methylbenzoyl-1-naphthylamin-4,6,8-trisulfonsaeure; 1,3,5-Naphthalenetrisulfonic acid, 8,8'-(carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bis-; Spectrum4_001247; Sodium suramin.
show more » |
DrugBank
Identification
| Name: | Suramin |
|---|---|
| Name (isomeric): | DB04786 |
| Drug Type: | small molecule |
| Description: | A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties. |
| Synonyms: |
Sodium suramin; Suramine sodium; Bayer 205; Suramine; Suramin sodium; SVR
|
| Brand: | Moranyl, Germanin, Naphuride, Farma, Belganyl, Naganine, Fourneau, Naganin, Antrypol, Naganol, Naganil |
| Category: | Trypanocidal Agents, Antineoplastic Agents, Antinematodal Agents |
| CAS number: | 145-63-1 |
Pharmacology
| Indication: | For treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms. |
|---|---|
| Mechanism of Action: |
The mechanism is unknown, but the trypanocidal activity may be due to the inhibition of enzymes involved with the oxidation of reduced nicotinamide-adenine dinucleotide (NADH), which functions as a co-enzyme in many cellular reactions, such as respiration and glycolysis, in the trypanosome parasite. Suramin's action in the treatment of onchocercias...
show more » |
| Absorption: | Poorly absorbed from the gastrointestinal tract. |
| Protein binding: | Approximately 99.7% |
| Biotransformation: | Little or no metabolism |
| Half Life: | Approximately 36 to 60 days |
| Affected organisms: | Yeast, Molds, Trypanosomes |
Targets
