QuickView for Symplekin (gene)

Gene Symbol:

SYMPK Homo sapiens

Full name:

symplekin

Synonyms:

SPK, SYM, symplekin

Genomic Location:

Chr 19: 51010540-51058388

Description:

This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-en...

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This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

STAT1_02 ,  GGAMTNNNNNTCCY_UNKNOWN ,  STAT1_03 ,  COUP_01 ,  ATGGYGGA_UNKNOWN ,  HNF4_DR1_Q3 ,  TATAAA_TATA_01 ,  STAT5B_01 ,  TNCATNTCCYR_UNKNOWN ,  AP2_Q6_01 ,  AR_01 ,  GGGCGGR_SP1_Q6 ,  YKACATTT_UNKNOWN ,  GATA2_01 ,  STAT_01 ,  COUP_DR1_Q6 ,  TTCYNRGAA_STAT5B_01 ,  STAT5A_01 ,  RCGCANGCGY_NRF1_Q6 ,  FOXM1_01 ,  NFKB_C ,  RACTNNRTTTNC_UNKNOWN ,  STAT5A_02

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Cytogenetic Map:

19q13.32

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