QuickView for TAAV688 (gene)
- Gene Symbol:
- APH1B
Homo sapiens - Full name:
- aph-1 homolog B, gamma-secretase subunit
- Synonyms:
- APH-1B, PRO1328, PSFL, TAAV688, gamma-secretase subunit APH-1B, APH1B gamma secretase subunit, anterior pharynx defective 1 homolog B, aph-1beta
- Genomic Location:
- Chr 15: 61356844-61385166
- Description:
-
This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptor...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
15q22.2
GO Molecular Function
hydrolase activity | catalytic activity | protein binding | endopeptidase activity | peptidase activity
GO Biological Process
membrane protein proteolysis | Notch signaling pathway | proteolysis | protein processing | cellular process | positive regulation of catalytic activity | regulation of cellular process | response to stimulus | Notch receptor processing, ligand-dependent | nitrogen compound metabolic process | regulation of catalytic activity | membrane protein intracellular domain proteolysis | protein maturation | cell communication | positive regulation of molecular function | protein metabolic process | cell surface receptor signaling pathway | Notch receptor processing | metabolic process | organic substance metabolic process | gene expression | signaling | endopeptidase activity | cellular protein metabolic process | cellular metabolic process | peptidase activity | signal transduction | macromolecule metabolic process
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | plasma membrane protein complex | intrinsic component of membrane | cytoplasm | gamma-secretase complex | intracellular organelle | endoplasmic reticulum | protein-containing complex | endomembrane system | plasma membrane | vesicle | transport vesicle | integral component of plasma membrane | membrane-bounded organelle | organelle | cell periphery | intracellular vesicle | intracellular | membrane | intrinsic component of plasma membrane
