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QuickView for TAB3;jsessionid=E10958033198F1D4407FD5100F9BBB26 (gene)


Gene Symbol:
TAB3 Homo sapiens Homo sapiens
Full name:
TGF-beta activated kinase 1 and MAP3K7 binding protein 3
Synonyms:
MAP3K7IP3, NAP1, TGF-beta-activated kinase 1 and MAP3K7-binding protein 3, NF-kappa-B-activating protein 1, NFkB activating protein 1, TAB-3, TAK1-binding protein 3, TGF-beta activated kinase 1/MAP3K7 binding protein 3, TGF-beta-activated kinase 1-binding protein 3, mitogen-activated protein kinase kinase kinase 7 interacting protein 3
Genomic Location:
Chr X: 30755480-30817432
Description:
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/T...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr X
Xp21.2





GO Molecular Function

cation binding | ion binding | protein binding | metal ion binding

GO Biological Process

positive regulation of immune response | nucleotide-binding oligomerization domain containing signaling pathway | response to cytokine | response to interleukin-1 | immune response-regulating signaling pathway | intracellular signal transduction | positive regulation of DNA-binding transcription factor activity | immune response-regulating cell surface receptor signaling pathway | regulation of autophagy | regulation of immune system process | negative regulation of cellular process | regulation of MAP kinase activity | immune response-activating cell surface receptor signaling pathway | positive regulation of phosphate metabolic process | innate immune response activating cell surface receptor signaling pathway | innate immune response-activating signal transduction | cellular process | toll-like receptor signaling pathway | positive regulation of protein kinase activity | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of immune response | regulation of cellular process | regulation of metabolic process | positive regulation of cellular protein metabolic process | MAPK cascade | response to stimulus | JNK cascade | positive regulation of innate immune response | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | response to stress | activation of innate immune response | immune response-activating signal transduction | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | protein modification process | macromolecule modification | activation of protein kinase activity | stress-activated protein kinase signaling cascade | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | regulation of signal transduction | pattern recognition receptor signaling pathway | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of gene expression | cellular response to stress | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | interleukin-1-mediated signaling pathway | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | Fc-epsilon receptor signaling pathway | cellular response to cytokine stimulus | stress-activated MAPK cascade | regulation of cellular protein metabolic process | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | negative regulation of autophagy | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | regulation of RNA metabolic process | positive regulation of molecular function | activation of MAPK activity | activation of immune response | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | protein metabolic process | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | regulation of kinase activity | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | organic substance metabolic process | positive regulation of NF-kappaB transcription factor activity | positive regulation of kinase activity | regulation of phosphate metabolic process | positive regulation of MAPK cascade | intracellular receptor signaling pathway | regulation of cell communication | signaling | regulation of transcription, DNA-templated | I-kappaB kinase/NF-kappaB signaling | positive regulation of phosphorylation | cellular protein metabolic process | positive regulation of MAP kinase activity | Fc receptor signaling pathway | cellular response to interleukin-1 | cellular protein modification process | MyD88-dependent toll-like receptor signaling pathway | stimulatory C-type lectin receptor signaling pathway | positive regulation of metabolic process | immune system process | cellular metabolic process | cellular response to organic substance | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | regulation of phosphorus metabolic process

GO Cellular Component

organelle membrane | cytoplasmic vesicle | cell | cytoplasm | intracellular organelle | endosome membrane | endomembrane system | plasma membrane | vesicle | extracellular exosome | endosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | cytosol | intracellular vesicle | intracellular | membrane