QuickView for TACC2;jsessionid=9F1BF395348C72FFB30E42D9C13E58F9 (gene)

Gene Symbol:

TACC2 Homo sapiens

Full name:

transforming acidic coiled-coil containing protein 2

Synonyms:

AZU-1, ECTACC, transforming acidic coiled-coil-containing protein 2, anti zuai-1

Genomic Location:

Chr 10: 123738679-124004047

Description:

Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by ery...

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Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  ATGCAGT_MIR217 ,  NFAT_Q6 ,  CTACTGT_MIR199A ,  STAT6_01 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  AML1_01 ,  GGGAGGRR_MAZ_Q6 ,  TGAYRTCA_ATF3_Q6 ,  CAGGTG_E12_Q6 ,  AP2_Q6_01 ,  TGCCTTA_MIR124A ,  YGCANTGCR_UNKNOWN ,  ATGTTTC_MIR494 ,  RACCACAR_AML_Q6 ,  AREB6_03 ,  HMGIY_Q6 ,  AML1_Q6 ,  IK2_01 ,  CTGCAGY_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  BRN2_01 ,  TGACATY_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-217 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-31

Cytogenetic Map:

10q26.13

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