QuickView for TAF10 (gene)

Gene Symbol:

TAF10 Homo sapiens

Full name:

TATA-box binding protein associated factor 10

Synonyms:

TAF2A, TAF2H, TAFII30, transcription initiation factor TFIID subunit 10, STAF28, TAF(II)30, TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa, TAFII-30, TATA box binding protein (TBP)-associated factor, RNA polymerase II, H, 30kD, transcription initiation factor TFIID 30 kD subunit, transcription initiation factor TFIID 30 kDa subunit

Genomic Location:

Chr 11: 6588649-6590021

Description:

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as...

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Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GABP_B ,  HFH1_01 ,  ACTTTAT_MIR1425P ,  GGGAGGRR_MAZ_Q6 ,  YAATNRNNNYNATT_UNKNOWN ,  GTGACGY_E4F1_Q6 ,  GGAANCGGAANY_UNKNOWN ,  E4F1_Q6 ,  HSF_Q6 ,  HAND1E47_01 ,  SCGGAAGY_ELK1_02 ,  TEF_Q6 ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  AACTTT_UNKNOWN ,  TCCCCAC_MIR491 ,  DR4_Q2

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-491

Cytogenetic Map:

11p15.4

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