QuickView for TAFII100 (gene)

Gene Symbol:

TAF5 Homo sapiens

Full name:

TATA-box binding protein associated factor 5

Synonyms:

TAF(II)100, TAF2D, TAFII-100, TAFII100, transcription initiation factor TFIID subunit 5, TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa, TATA box binding protein (TBP)-associated factor 2D, TATA box binding protein (TBP)-associated factor, RNA polymerase II, D, 100kD, transcription initiation factor TFIID 100 kD subunit, transcription initiation factor TFIID 100 kDa subunit

Genomic Location:

Chr 10: 105117714-105138812

Description:

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as...

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Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes an integral subunit of TFIID associated with all transcriptionally competent forms of that complex. This subunit interacts strongly with two TFIID subunits that show similarity to histones H3 and H4, and it may participate in forming a nucleosome-like core in the TFIID complex. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Bos taurus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTATTAT_MIR3693P ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  TGIF_01 ,  RYTTCCTG_ETS2_B ,  P53_DECAMER_Q2 ,  AAAGGGA_MIR204_MIR211 ,  FOXO4_01 ,  CTACTGT_MIR199A ,  TTCCGTT_MIR191 ,  CCAGGTT_MIR490 ,  CTATGCA_MIR153 ,  PEA3_Q6 ,  TEL2_Q6 ,  PAX8_01 ,  CTCNANGTGNY_UNKNOWN ,  WHN_B ,  PAX2_01 ,  CATTTCA_MIR203 ,  ATACCTC_MIR202 ,  ETS2_B ,  CAGCTTT_MIR320 ,  TGCGCANK_UNKNOWN ,  ATGCTGC_MIR103_MIR107 ,  GGGCGGR_SP1_Q6 ,  MGGAAGTG_GABP_B ,  PAX6_01 ,  AAAGACA_MIR511 ,  GCM_Q2 ,  PAX8_B ,  CACGTTT_MIR302A ,  HMGIY_Q6 ,  ELK1_01 ,  TTGTTT_FOXO4_01 ,  IRF7_01 ,  CTGAGCC_MIR24 ,  TGCTTTG_MIR330 ,  PAX_Q6 ,  TGACAGNY_MEIS1_01 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  PAX4_01 ,  MYB_Q3

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-191 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-488 ,  Predicted Gene Targets for miR-490 ,  Predicted Gene Targets for miR-543

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Cytogenetic Map:

10q24.33

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