QuickView for TAFII28 (gene)

Gene Symbol:

TAF11 Homo sapiens

Full name:

TATA-box binding protein associated factor 11

Synonyms:

MGC:15243, PRO2134, TAF2I, TAFII28, transcription initiation factor TFIID subunit 11, TAF(II)28, TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa, TAFII-28, TATA box binding protein (TBP)-associated factor, RNA polymerase II, I, 28kD, TFIID subunit p30-beta, transcription initiation factor TFIID 28 kD subunit, transcription initiation factor TFIID 28 kDa subunit

Genomic Location:

Chr 6: 34953533-34963797

Description:

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as...

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Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CGTSACG_PAX3_B ,  LXR_DR4_Q3 ,  ATF4_Q2 ,  MYCMAX_B ,  EGR2_01 ,  TGAYRTCA_ATF3_Q6 ,  PAX2_01 ,  GTGACGY_E4F1_Q6 ,  CAGGTG_E12_Q6 ,  SP1_Q4_01 ,  GGGCGGR_SP1_Q6 ,  GCGNNANTTCC_UNKNOWN ,  MGGAAGTG_GABP_B ,  SP1_Q6 ,  AHRARNT_01 ,  TTGTTT_FOXO4_01 ,  SCGGAAGY_ELK1_02 ,  CCGNMNNTNACG_UNKNOWN ,  EGR1_01 ,  ZF5_B ,  AACTTT_UNKNOWN ,  EGR3_01 ,  PAX4_01 ,  TAXCREB_01

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Cytogenetic Map:

6p21.31

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