QuickView for TAFII68 (gene)

Gene Symbol:

TAF15 Homo sapiens

Full name:

TATA-box binding protein associated factor 15

Synonyms:

Npl3, RBP56, TAF2N, TAFII68, TATA-binding protein-associated factor 2N, RBP56/CSMF fusion, TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa, TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56), TATA box-binding protein-associated factor 2N (RNA-binding protein 56), TBP-associated factor 15

Genomic Location:

Chr 17: 31160601-31198351

Description:

This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma,...

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This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  TGANTCA_AP1_C ,  AP3_Q6 ,  E4BP4_01 ,  NFY_C ,  YATTNATC_UNKNOWN ,  TTF1_Q6 ,  GCCATNTTG_YY1_Q6 ,  GGGAGGRR_MAZ_Q6 ,  CDP_01 ,  PAX5_02 ,  ALPHACP1_01 ,  CAGGTG_E12_Q6 ,  BACH2_01 ,  GGGCGGR_SP1_Q6 ,  NFY_01 ,  NFY_Q6 ,  TGTTTGY_HNF3_Q6 ,  GACTGTT_MIR212_MIR132 ,  KCCGNSWTTT_UNKNOWN ,  TTGCCAA_MIR182 ,  CCTGCTG_MIR214 ,  WTTGKCTG_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  AP1_Q4_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182

Cytogenetic Map:

17q12

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