QuickView for TBC1D1 (gene)

Gene Symbol:

TBC1D1 Homo sapiens

Full name:

TBC1 domain family member 1

Synonyms:

TBC, TBC1, TBC1 domain family member 1, TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1

Genomic Location:

Chr 4: 37569115-37817189

Description:

TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000 [PubMed 10965142]).

TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000 [PubMed 10965142]).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  CTCAGGG_MIR125B_MIR125A ,  GTGCCTT_MIR506

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-543

Cytogenetic Map:

4p14

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