QuickView for TBC1D8B;jsessionid=9E003ACDB8773ABA4447750E575D6318 (gene)
- Gene Symbol:
- TBC1D8B
Homo sapiens - Full name:
- TBC1 domain family member 8B
- Synonyms:
- GRAMD8B, TBC1 domain family member 8B, RP11-321G1.1, TBC1 domain family, member 8B (with GRAM domain)
- Genomic Location:
- Chr X: 105932575-106006036
- Description:
-
This gene encodes a protein with a TBC (Tre-2/Bub2/CDC16) domain. Some mammalian proteins with this domain have been shown to function as Rab-GAPs by binding to specific Rab proteins and affecting their GTPase activity. Alternative splicing results in multiple transcript variants.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Schizosaccharomyces pombe , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
Xq22.3
GO Molecular Function
enzyme activator activity | GTPase binding | cation binding | GTPase activator activity | enzyme binding | GTPase regulator activity | Ras GTPase binding | molecular function regulator | ion binding | protein binding | small GTPase binding | Rab GTPase binding | calcium ion binding | enzyme regulator activity | metal ion binding
GO Biological Process
activation of GTPase activity | enzyme activator activity | establishment of localization | intracellular transport | positive regulation of GTPase activity | localization | protein transport | GTPase activator activity | macromolecule localization | positive regulation of catalytic activity | establishment of localization in cell | GTPase regulator activity | intracellular protein transport | cellular localization | molecular function regulator | regulation of catalytic activity | organic substance transport | peptide transport | positive regulation of hydrolase activity | regulation of GTPase activity | positive regulation of molecular function | cellular protein localization | amide transport | establishment of protein localization | protein localization | enzyme regulator activity | cellular macromolecule localization
GO Cellular Component
