QuickView for TBL1XR1;jsessionid=753345F2F49CF6930C0E50EA4B45577D (gene)

Gene Symbol:

TBL1XR1 Homo sapiens

Full name:

transducin beta like 1 X-linked receptor 1

Synonyms:

C21, DC42, IRA1, MRD41, TBLR1, F-box-like/WD repeat-containing protein TBL1XR1, TBL1-related protein 1, nuclear receptor co-repressor/HDAC3 complex subunit, nuclear receptor corepressor/HDAC3 complex subunit TBLR1

Genomic Location:

Chr 3: 178221867-178397734

Description:

This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a var...

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This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGCC_MIR34A_MIR34C_MIR449 ,  GTGTTGA_MIR505 ,  PR_02 ,  AAGCCAT_MIR135A_MIR135B ,  GCATTTG_MIR105 ,  CCCAGAG_MIR326 ,  RYTTCCTG_ETS2_B ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  AP3_Q6 ,  TTTTGAG_MIR373 ,  CATTGTYY_SOX9_B1 ,  ATTACAT_MIR3803P ,  FOXD3_01 ,  TTTGTAG_MIR520D ,  CAGTGTT_MIR141_MIR200A ,  WGTTNNNNNAAA_UNKNOWN ,  ATGTACA_MIR493 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  CTTTGA_LEF1_Q2 ,  GR_Q6_01 ,  GTGCAAA_MIR507 ,  TGACCTY_ERR1_Q2 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  TCF4_Q5 ,  TATAAA_TATA_01 ,  GCTGAGT_MIR5125P ,  CDX2_Q5 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  TTCYRGAA_UNKNOWN ,  CAGCTTT_MIR320 ,  ATTCTTT_MIR186 ,  ATGCTGC_MIR103_MIR107 ,  IRF_Q6 ,  ACTGAAA_MIR30A3P_MIR30E3P ,  SOX5_01 ,  ATACTGT_MIR144 ,  CCTGCTG_MIR214 ,  TTGTTT_FOXO4_01 ,  GR_01 ,  GGCCAGT_MIR193A_MIR193B ,  AAGCACT_MIR520F ,  TGACATY_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ATGAAGG_MIR205 ,  TGACCTTG_SF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-193 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-216 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-324-5p ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-542-3p ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-376 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-363 ,  Predicted Gene Targets for miR-409-5p ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-500 ,  Predicted Gene Targets for miR-505

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Cytogenetic Map:

3q26.32

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