QuickView for TCF7L2 (gene)
- Gene Symbol:
- TCF7L2
Homo sapiens - Full name:
- transcription factor 7 like 2
- Synonyms:
- TCF-4, TCF4, transcription factor 7-like 2, HMG box transcription factor 4, T-cell factor 4, T-cell-specific transcription factor 4, hTCF-4, transcription factor 7-like 2 (T-cell specific, HMG-box)
- Genomic Location:
- Chr 10: 114700201-114916063
- Description:
-
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
RTAAACA_FREAC2_01 , FREAC7_01 , HNF3ALPHA_Q6 , ALX4_01 , MAZR_01 , MAZ_Q6 , FOX_Q2 , HFH3_01 , AAAYWAACM_HFH4_01 , FOXD3_01
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
10q25.2-q25.3
GO Molecular Function
sequence-specific DNA binding | beta-catenin binding | kinase binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | repressing transcription factor binding | hormone receptor binding | protein kinase binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | signaling receptor binding | chromatin binding | protein domain specific binding | RNA polymerase II repressing transcription factor binding | RNA polymerase II regulatory region DNA binding | gamma-catenin binding | armadillo repeat domain binding | DNA binding | sequence-specific double-stranded DNA binding | nuclear hormone receptor binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | RNA polymerase II regulatory region sequence-specific DNA binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | positive regulation of macromolecule biosynthetic process | regulation of intracellular protein transport | regulation of cellular localization | regulation of localization | regulation of programmed cell death | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | cell differentiation | glucose homeostasis | regulation of peptide hormone secretion | positive regulation of protein secretion | positive regulation of cellular biosynthetic process | cellular process | positive regulation of glycoprotein biosynthetic process | negative regulation of signaling | positive regulation of protein export from nucleus | canonical Wnt signaling pathway | positive regulation of epithelial to mesenchymal transition | negative regulation of nucleic acid-templated transcription | negative regulation of apoptotic process | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | regulation of canonical Wnt signaling pathway | regulation of protein export from nucleus | negative regulation of cellular metabolic process | regulation of binding | regulation of cell differentiation | muscle structure development | negative regulation of apoptotic signaling pathway | regulation of protein kinase B signaling | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | positive regulation of protein binding | regulation of peptide secretion | response to stimulus | negative regulation of epithelial cell apoptotic process | positive regulation of heparan sulfate proteoglycan biosynthetic process | vasculature development | regulation of glycoprotein biosynthetic process | regulation of cellular protein localization | regulation of insulin secretion | positive regulation of protein metabolic process | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | response to glucose | beta-catenin-TCF complex assembly | cardiovascular system development | cellular nitrogen compound metabolic process | positive regulation of hormone secretion | regulation of protein transport | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | regulation of peptide transport | cellular biosynthetic process | cell-cell signaling | regulation of intracellular transport | cell surface receptor signaling pathway involved in cell-cell signaling | blood vessel development | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | system development | nitrogen compound metabolic process | regulation of signal transduction | Wnt signaling pathway | multicellular organism development | positive regulation of protein kinase B signaling | regulation of hormone levels | regulation of hormone secretion | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | myoblast fate commitment | pancreas development | positive regulation of secretion | cell cycle | positive regulation of intracellular protein transport | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | negative regulation of DNA-binding transcription factor activity | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | fat cell differentiation | positive regulation of cell differentiation | negative regulation of extrinsic apoptotic signaling pathway | non-canonical Wnt signaling pathway | cell proliferation | biosynthetic process | regulation of hormone metabolic process | aromatic compound biosynthetic process | regulation of apoptotic signaling pathway | maintenance of DNA repeat elements | regulation of epithelial cell apoptotic process | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | response to monosaccharide | positive regulation of establishment of protein localization | regulation of RNA metabolic process | positive regulation of transport | positive regulation of peptide hormone secretion | canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition | positive regulation of molecular function | regulation of nucleocytoplasmic transport | Wnt signaling pathway, calcium modulating pathway | protein-containing complex assembly | DNA-binding transcription factor activity | regulation of establishment of protein localization | response to organic substance | negative regulation of type B pancreatic cell apoptotic process | positive regulation of insulin secretion | cell cycle arrest | DNA metabolic process | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | metabolic process | cell fate commitment | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | chemical homeostasis | regulation of secretion | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | positive regulation of proteoglycan biosynthetic process | regulation of protein secretion | regulation of Wnt signaling pathway | positive regulation of binding | positive regulation of glycoprotein metabolic process | transcription, DNA-templated | positive regulation of intracellular transport | positive regulation of protein transport | negative regulation of cell cycle | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | regulation of protein binding | myoblast differentiation | cellular macromolecule biosynthetic process | regulation of developmental process | developmental process | negative regulation of canonical Wnt signaling pathway | organelle organization | negative regulation of transcription by RNA polymerase II | regulation of transport | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | regulation of epithelial to mesenchymal transition | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | negative regulation of Wnt signaling pathway | cellular metabolic process | regulation of protein localization | regulation of cell death | regulation of smooth muscle cell proliferation | response to carbohydrate | negative regulation of cell death | circulatory system development | carbohydrate homeostasis | positive regulation of nucleocytoplasmic transport | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
nuclear transcription factor complex | chromosome | catenin-TCF7L2 complex | intracellular membrane-bounded organelle | RNA polymerase II transcription factor complex | cell | nuclear lumen | transcription factor complex | intracellular organelle | nuclear body | protein-containing complex | PML body | protein-DNA complex | nucleoplasm | chromatin | nuclear chromosome | beta-catenin-TCF7L2 complex | beta-catenin-TCF complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | intracellular
