QuickView for TDO2 (gene)

Gene Symbol:

TDO2 Homo sapiens

Full name:

tryptophan 2,3-dioxygenase

Synonyms:

HYPTRP, TDO, TO, TPH2, TRPO, tryptophan 2,3-dioxygenase, tryptamin 2,3-dioxygenase, tryptophan oxygenase, tryptophan pyrrolase, tryptophanase

Genomic Location:

Chr 4: 157044297-157061000

Description:

This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polym...

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This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  TATAAA_TATA_01 ,  ALPHACP1_01 ,  NFY_01 ,  NFY_Q6 ,  WTTGKCTG_UNKNOWN ,  GCTNWTTGK_UNKNOWN

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-493-5p

Cytogenetic Map:

4q32.1

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