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QuickView for TEM2 (gene)


Gene Symbol:
RASD2 Homo sapiens Homo sapiens
Full name:
RASD family member 2
Synonyms:
MGC:4834, Rhes, TEM2, GTP-binding protein Rhes, Ras homolog enriched in striatum, tumor endothelial marker 2
Genomic Location:
Chr 22: 34267298-34279992
Description:
This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degenerati...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 22
22q12.3





GO Molecular Function

phosphatidylinositol 3-kinase binding | guanyl ribonucleotide binding | ribonucleoside binding | enzyme binding | ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | pyrophosphatase activity | catalytic activity | anion binding | nucleoside-triphosphatase activity | ubiquitin conjugating enzyme binding | purine nucleotide binding | ion binding | organic cyclic compound binding | GTPase activity | purine nucleoside binding | purine ribonucleoside triphosphate binding | protein binding | G-protein beta-subunit binding | GTP binding | hydrolase activity, acting on acid anhydrides | ubiquitin-like protein conjugating enzyme binding | nucleoside binding | purine ribonucleotide binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | guanyl nucleotide binding | small molecule binding

GO Biological Process

negative regulation of cellular process | cellular process | chemical synaptic transmission | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of protein kinase B signaling | regulation of cellular process | regulation of metabolic process | positive regulation of cellular protein metabolic process | response to stimulus | positive regulation of protein metabolic process | regulation of protein ubiquitination | negative regulation of metabolic process | cell-cell signaling | synaptic transmission, dopaminergic | regulation of signal transduction | positive regulation of protein sumoylation | positive regulation of protein kinase B signaling | synaptic signaling | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | locomotory behavior | regulation of cellular protein metabolic process | regulation of protein sumoylation | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | regulation of cAMP-mediated signaling | negative regulation of protein ubiquitination | positive regulation of protein modification process | regulation of intracellular signal transduction | behavior | negative regulation of cellular protein metabolic process | negative regulation of protein metabolic process | regulation of cell communication | signaling | positive regulation of metabolic process | positive regulation of signaling | signal transduction | regulation of signaling

GO Cellular Component

cell | plasma membrane | cell periphery | membrane