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QuickView for TFAP2A (gene)


Gene Symbol:
TFAP2A Homo sapiens Homo sapiens
Full name:
transcription factor AP-2 alpha
Synonyms:
AP-2, AP-2alpha, AP2TF, BOFS, TFAP2, transcription factor AP-2-alpha, AP-2 transcription factor, AP2-alpha, activating enhancer-binding protein 2-alpha, activator protein 2, transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Genomic Location:
Chr 6: 10504902-10527783
Description:
The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of br...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 6
6p24.3





GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | chromatin binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | identical protein binding | organic cyclic compound binding | transcription coactivator activity | transcription regulatory region sequence-specific DNA binding | protein binding | protein homodimerization activity | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transcription coregulator activity | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | limb development | inner ear morphogenesis | positive regulation of macromolecule biosynthetic process | cranial skeletal system development | positive regulation of apoptotic process | morphogenesis of an epithelium | regulation of programmed cell death | eye development | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | positive regulation of developmental process | embryonic camera-type eye morphogenesis | negative regulation of RNA biosynthetic process | embryonic appendage morphogenesis | response to metal ion | bone development | nervous system development | positive regulation of biomineral tissue development | cellular response to iron ion | sensory perception of mechanical stimulus | regulation of neuron death | neural retina development | positive regulation of cellular biosynthetic process | cellular process | limb morphogenesis | optic cup morphogenesis involved in camera-type eye development | negative regulation of nucleic acid-templated transcription | negative regulation of apoptotic process | positive regulation of nitrogen compound metabolic process | retina layer formation | response to inorganic substance | negative regulation of cellular metabolic process | regulation of bone mineralization | tissue development | regulation of cell differentiation | autonomic nervous system development | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | cranial nerve morphogenesis | organic cyclic compound metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | oculomotor nerve formation | cellular response to metal ion | urogenital system development | anatomical structure arrangement | optic vesicle morphogenesis | cranial nerve development | response to stimulus | embryonic limb morphogenesis | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | roof of mouth development | cellular response to inorganic substance | embryonic skeletal system development | cellular nitrogen compound metabolic process | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | regulation of odontogenesis | cellular biosynthetic process | kidney development | embryo development | response to iron ion | parasympathetic nervous system development | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | multicellular organism development | retina morphogenesis in camera-type eye | regulation of ossification | regulation of gene expression | forelimb morphogenesis | nervous system process | positive regulation of cellular metabolic process | eyelid development in camera-type eye | animal organ morphogenesis | regulation of nitrogen compound metabolic process | embryonic forelimb morphogenesis | regulation of transcription by RNA polymerase II | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | embryonic camera-type eye development | biosynthetic process | aromatic compound biosynthetic process | positive regulation of ossification | positive regulation of odontogenesis | positive regulation of neuron death | sensory organ development | chordate embryonic development | regulation of cellular metabolic process | eye morphogenesis | regulation of neuron apoptotic process | skeletal system morphogenesis | sensory perception of sound | inner ear development | bone morphogenesis | embryo development ending in birth or egg hatching | transcription coactivator activity | regulation of RNA metabolic process | renal system development | embryonic morphogenesis | embryonic organ morphogenesis | embryonic cranial skeleton morphogenesis | optic cup structural organization | oculomotor nerve development | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | tissue morphogenesis | retina development in camera-type eye | regulation of animal organ morphogenesis | positive regulation of neuron apoptotic process | anatomical structure development | embryonic skeletal system morphogenesis | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | embryonic organ development | ear development | positive regulation of cell death | morphogenesis of embryonic epithelium | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | embryonic camera-type eye formation | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | nerve development | gene expression | positive regulation of programmed cell death | transcription, DNA-templated | camera-type eye development | anatomical structure formation involved in morphogenesis | sensory perception | regulation of transcription, DNA-templated | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | camera-type eye morphogenesis | trigeminal nerve development | negative regulation of transcription by competitive promoter binding | regulation of developmental process | developmental process | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | negative regulation of cell proliferation | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | central nervous system development | positive regulation of metabolic process | skeletal system development | cellular metabolic process | embryonic eye morphogenesis | regulation of cell death | negative regulation of cell death | ear morphogenesis | positive regulation of bone mineralization | negative regulation of reactive oxygen species metabolic process | positive regulation of gene expression | macromolecule metabolic process | positive regulation of tooth mineralization | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | microtubule organizing center | cell | nuclear lumen | cytoplasm | intracellular organelle | centrosome | Golgi apparatus | endomembrane system | nucleoplasm | microtubule cytoskeleton | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | cytoskeleton | intracellular