QuickView for TFAP2B (gene)

Gene Symbol:

TFAP2B Homo sapiens

Full name:

transcription factor AP-2 beta

Synonyms:

AP-2B, AP2-B, PDA2, transcription factor AP-2-beta, AP2-beta, activating enhancer binding protein 2 beta

Genomic Location:

Chr 6: 50894398-50923285

Description:

This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members dif...

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This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  TFIIA_Q6 ,  FOXJ2_02 ,  HOXA4_Q2 ,  WGTTNNNNNAAA_UNKNOWN ,  TAAYNRNNTCC_UNKNOWN ,  TAGCTTT_MIR9 ,  SREBP1_Q6 ,  TTAYRTAA_E4BP4_01 ,  TATAAA_TATA_01 ,  RYTGCNWTGGNR_UNKNOWN ,  SOX9_B1 ,  SOX5_01 ,  RNGTGGGC_UNKNOWN ,  CHX10_01 ,  TTGTTT_FOXO4_01 ,  CHOP_01 ,  TEF_Q6 ,  TACAATC_MIR508 ,  SRY_02 ,  PAX4_03 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-320

Cytogenetic Map:

6p12.3

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