QuickView for TFB1M;jsessionid=F7402770BB61156DD2B37E9C7D478CE9 (gene)

Gene Symbol:

TFB1M Homo sapiens

Full name:

transcription factor B1, mitochondrial

Synonyms:

CGI-75, CGI75, mtTFB, mtTFB1, dimethyladenosine transferase 1, mitochondrial, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1, h-mtTFB1, hTFB1M, homolog of yeast mitochondrial transcription factor B, mitochondrial 12S rRNA dimethylase 1, mitochondrial dimethyladenosine transferase 1

Genomic Location:

Chr 6: 155620482-155677318

Description:

The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one anoth...

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The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  RYTTCCTG_ETS2_B ,  YTATTTTNR_MEF2_02 ,  GFI1_01 ,  TTGTTT_FOXO4_01

Cytogenetic Map:

6q25.3

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