QuickView for TFIIA (gene)
- Gene Symbol:
- GTF2A1
Homo sapiens - Full name:
- general transcription factor IIA subunit 1
- Synonyms:
- TF2A1, TFIIA, TFIIA-42, TFIIAL, transcription initiation factor IIA subunit 1, TFIIA alpha, p55, TFIIA alpha/beta subunits, general transcription factor IIA 1, general transcription factor IIA, 1, 19/37kDa, glucose regulated protein, 58kD pseudogene, transcription initiation factor TFIIA 42 kDa subunit
- Genomic Location:
- Chr 14: 80716147-80757328
- Description:
-
Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
14q31.1
GO Molecular Function
repressing transcription factor binding | nucleic acid binding | RNA polymerase II repressing transcription factor binding | DNA binding | protein heterodimerization activity | organic cyclic compound binding | transcription coactivator activity | protein binding | transcription factor binding | TBP-class protein binding | RNA polymerase II transcription factor binding | protein dimerization activity | transcription coregulator activity | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | DNA-templated transcription, initiation | positive regulation of macromolecule biosynthetic process | snRNA metabolic process | positive regulation of cellular biosynthetic process | cellular process | positive regulation of nitrogen compound metabolic process | snRNA transcription | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular nitrogen compound biosynthetic process | snRNA transcription by RNA polymerase II | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | ncRNA transcription | regulation of gene expression | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | biosynthetic process | aromatic compound biosynthetic process | regulation of cellular metabolic process | transcription coactivator activity | regulation of RNA metabolic process | metabolic process | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | ncRNA metabolic process | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | macromolecule metabolic process
GO Cellular Component
nuclear transcription factor complex | intracellular membrane-bounded organelle | catalytic complex | transcription factor TFIIA complex | RNA polymerase II transcription factor complex | cell | nuclear lumen | transcription factor complex | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | transferase complex | membrane-bounded organelle | nucleus | organelle | nuclear DNA-directed RNA polymerase complex | transcription factor TFIID complex | RNA polymerase complex | membrane-enclosed lumen | cytosol | intracellular | RNA polymerase II, holoenzyme
