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QuickView for TFR1 (gene)


Gene Symbol:
TFRC Homo sapiens Homo sapiens
Full name:
transferrin receptor
Synonyms:
CD71, IMD46, T9, TFR, TFR1, TR, TRFR, p90, transferrin receptor protein 1
Genomic Location:
Chr 3: 197260744-197293338
Description:
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Canis lupus familiaris Pan troglodytes Danio rerio Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 3
3q29





GO Molecular Function

transition metal ion transmembrane transporter activity | ferric iron transmembrane transporter activity | nucleic acid binding | transmembrane transporter activity | transferrin receptor activity | cation transmembrane transporter activity | transporter activity | identical protein binding | ion transmembrane transporter activity | organic cyclic compound binding | protein binding | protein homodimerization activity | iron ion transmembrane transporter activity | metal ion transmembrane transporter activity | protein dimerization activity | transferrin transmembrane transporter activity | virus receptor activity | inorganic cation transmembrane transporter activity | heterocyclic compound binding | cargo receptor activity | RNA binding | double-stranded RNA binding

GO Biological Process

positive regulation of immune response | transition metal ion transmembrane transporter activity | ferric iron transmembrane transporter activity | response to cytokine | regulation of B cell activation | transferrin transport | iron ion transmembrane transport | establishment of localization | regulation of immune system process | myeloid cell differentiation | positive regulation of developmental process | positive regulation of lymphocyte activation | cell differentiation | response to drug | cellular chemical homeostasis | positive regulation of DNA recombination | positive regulation of cell adhesion | membrane organization | regulation of bone remodeling | cellular process | localization | cellular homeostasis | protein transport | metal ion transport | positive regulation of immune effector process | positive regulation of adaptive immune response | immune system development | macromolecule localization | transition metal ion transport | positive regulation of nitrogen compound metabolic process | iron ion import | interspecies interaction between organisms | regulation of immune response | regulation of cellular process | regulation of metabolic process | transmembrane transporter activity | cellular component organization | entry into host cell | viral life cycle | response to stimulus | regulation of DNA recombination | positive regulation of immune system process | positive regulation of immunoglobulin production | positive regulation of lymphocyte proliferation | regulation of cell proliferation | positive regulation of cell-cell adhesion | positive regulation of B cell proliferation | transferrin receptor activity | positive regulation of cell activation | positive regulation of T cell activation | hemopoiesis | regulation of cell adhesion | metal ion homeostasis | leukocyte differentiation | positive regulation of mononuclear cell proliferation | system development | multicellular organism development | ion transmembrane transport | regulation of T cell activation | viral entry into host cell | osteoclast differentiation | organic substance transport | cation transmembrane transporter activity | myeloid leukocyte differentiation | positive regulation of cellular metabolic process | regulation of lymphocyte activation | cellular ion homeostasis | regulation of nitrogen compound metabolic process | peptide transport | vesicle-mediated transport | ion transmembrane transporter activity | cellular response to cytokine stimulus | positive regulation of immunoglobulin mediated immune response | positive regulation of T cell proliferation | positive regulation of isotype switching | cation homeostasis | cellular response to drug | cellular cation homeostasis | regulation of cellular metabolic process | receptor internalization | ferric iron transport | homeostatic process | positive regulation of cell proliferation | iron ion homeostasis | positive regulation of B cell activation | viral process | cation transmembrane transport | iron ion transmembrane transporter activity | regulation of growth | response to organic substance | import into cell | metal ion transmembrane transporter activity | anatomical structure development | metabolic process | regulation of isotype switching | regulation of adaptive immune response | positive regulation of leukocyte activation | regulation of bone resorption | transferrin transmembrane transporter activity | regulation of tissue remodeling | amide transport | chemical homeostasis | endocytosis | organic substance metabolic process | virus receptor activity | animal organ development | regulation of cell activation | ion homeostasis | inorganic cation transmembrane transport | cellular iron ion homeostasis | establishment of protein localization | transmembrane transport | cellular response to leukemia inhibitory factor | regulation of immunoglobulin production | inorganic cation transmembrane transporter activity | regulation of T cell proliferation | protein localization | cation transport | iron ion transport | positive regulation of tissue remodeling | regulation of developmental process | receptor-mediated endocytosis | positive regulation of DNA metabolic process | developmental process | regulation of cell growth | regulation of B cell proliferation | regulation of cell-cell adhesion | receptor metabolic process | positive regulation of bone resorption | cellular metal ion homeostasis | positive regulation of metabolic process | ion transport | cargo receptor activity | transition metal ion homeostasis | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | positive regulation of leukocyte cell-cell adhesion | regulation of cellular component organization | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

integral component of membrane | clathrin-coated vesicle membrane | organelle membrane | clathrin-coated vesicle | cytoplasmic vesicle | cell | plasma membrane protein complex | HFE-transferrin receptor complex | intrinsic component of membrane | external side of plasma membrane | cytoplasm | intracellular organelle | receptor complex | melanosome | endosome membrane | protein-containing complex | recycling endosome | endomembrane system | plasma membrane | vesicle | perinuclear region of cytoplasm | clathrin-coated pit | extracellular exosome | integral component of plasma membrane | endosome | extracellular region | coated vesicle membrane | membrane-bounded organelle | extracellular vesicle | organelle | vesicle membrane | extracellular space | cell periphery | early endosome | basolateral plasma membrane | blood microparticle | intracellular vesicle | cell surface | intracellular | membrane | cytoplasmic vesicle membrane | intrinsic component of plasma membrane | coated vesicle