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QuickView for TGB1 (gene)


Gene Symbol:
PPBP Homo sapiens Homo sapiens
Full name:
pro-platelet basic protein
Synonyms:
B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1, platelet basic protein, C-X-C motif chemokine 7, CXC chemokine ligand 7, beta-thromboglobulin, chemokine (C-X-C motif) ligand 7, connective tissue-activating peptide III, leukocyte-derived growth factor, low-affinity platelet factor IV, macrophage-derived growth factor, neutrophil-activating peptide 2, small inducible cytokine B7, small inducible cytokine subfamily B, member 7, thrombocidin 1, thrombocidin 2, thromboglobulin, beta-1
Genomic Location:
Chr 4: 75071619-75072764
Description:
The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretio...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 4
4q13.3


Transcripts Names
NM_002704
Protein Names
B2R5F3
P02775
Q6IBJ8



GO Molecular Function

chemokine activity | transmembrane transporter activity | signaling receptor binding | cytokine receptor binding | molecular function regulator | transporter activity | sugar transmembrane transporter activity | chemokine receptor binding | glucose transmembrane transporter activity | protein binding | receptor regulator activity | growth factor activity | G-protein coupled receptor binding | receptor ligand activity | cytokine activity | carbohydrate transmembrane transporter activity | monosaccharide transmembrane transporter activity | hexose transmembrane transporter activity

GO Biological Process

exocytosis | response to cytokine | cell motility | neutrophil activation | response to lipopolysaccharide | defense response to other organism | establishment of localization | platelet degranulation | chemokine-mediated signaling pathway | defense response | cellular process | secretion | leukocyte degranulation | localization | chemokine activity | positive regulation of cell division | granulocyte chemotaxis | regulation of cellular process | leukocyte activation | cellular response to lipid | transmembrane transporter activity | cellular response to molecule of bacterial origin | regulation of cell division | response to stimulus | neutrophil degranulation | neutrophil chemotaxis | response to stress | leukocyte activation involved in immune response | monosaccharide transmembrane transport | secretion by cell | response to molecule of bacterial origin | G-protein coupled receptor signaling pathway | cell chemotaxis | molecular function regulator | leukocyte migration | locomotion | response to external biotic stimulus | regulation of signal transduction | cell migration | leukocyte mediated immunity | organic substance transport | response to lipid | cytokine-mediated signaling pathway | hexose transmembrane transport | vesicle-mediated transport | cellular response to cytokine stimulus | regulated exocytosis | sugar transmembrane transporter activity | response to bacterium | cell communication | antimicrobial humoral immune response mediated by antimicrobial peptide | humoral immune response | inflammatory response | cell activation involved in immune response | myeloid cell activation involved in immune response | neutrophil activation involved in immune response | leukocyte chemotaxis | defense response to bacterium | carbohydrate transport | glucose transmembrane transporter activity | carbohydrate transmembrane transport | regulation of signaling receptor activity | antimicrobial humoral response | receptor regulator activity | response to organic substance | cell surface receptor signaling pathway | growth factor activity | receptor ligand activity | immune response | cytokine activity | carbohydrate transmembrane transporter activity | cell activation | glucose transmembrane transport | regulation of cell communication | transmembrane transport | signaling | response to biotic stimulus | neutrophil mediated immunity | monosaccharide transmembrane transporter activity | hexose transmembrane transporter activity | immune system process | cellular response to organic substance | neutrophil migration | chemotaxis | response to other organism | signal transduction | regulation of signaling | cellular response to lipopolysaccharide

GO Cellular Component

secretory granule | tertiary granule | cytoplasmic vesicle | cell | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | platelet alpha granule | secretory vesicle | endomembrane system | vesicle | extracellular region | membrane-bounded organelle | organelle | extracellular space | tertiary granule lumen | membrane-enclosed lumen | secretory granule lumen | intracellular vesicle | intracellular | platelet alpha granule lumen | vesicle lumen