QuickView for TGD (gene)

Gene Symbol:

ABCA1 Homo sapiens

Full name:

ATP binding cassette subfamily A member 1

Synonyms:

ABC-1, ABC1, CERP, HDLDT1, TGD, ATP-binding cassette sub-family A member 1, ATP-binding cassette transporter A1, ATP-binding cassette, sub-family A (ABC1), member 1, cholesterol efflux regulatory protein, membrane-bound

Genomic Location:

Chr 9: 106583104-106730257

Description:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the AB...

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The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTTGTAT_MIR381 ,  RTAAACA_FREAC2_01 ,  GTGCCAT_MIR183 ,  FREAC7_01 ,  TTTGCAC_MIR19A_MIR19B ,  TFIIA_Q6 ,  ARNT_01 ,  CACGTG_MYC_Q2 ,  CTACTGT_MIR199A ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  LXR_DR4_Q3 ,  TTTGTAG_MIR520D ,  AACTGGA_MIR145 ,  ACTTTAT_MIR1425P ,  TTGCACT_MIR130A_MIR301_MIR130B ,  CTCNANGTGNY_UNKNOWN ,  ACTGTGA_MIR27A_MIR27B ,  CTTTGTA_MIR524 ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  TATA_C ,  MYCMAX_01 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  GGGCGGR_SP1_Q6 ,  USF_C ,  GTGCCAA_MIR96 ,  GCCNNNWTAAR_UNKNOWN ,  HFH8_01 ,  GTGCCTT_MIR506 ,  NMYC_01 ,  TATA_01 ,  SMAD4_Q6 ,  RORA2_01 ,  SRF_Q5_01 ,  AAGCACT_MIR520F ,  LXR_Q3 ,  GGCAGTG_MIR3243P ,  DR4_Q2 ,  CAATGCA_MIR33 ,  CACTTTG_MIR520G_MIR520H

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-376c

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Cytogenetic Map:

9q31.1

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