QuickView for TGE (gene)

Gene Symbol:

TGM3 Homo sapiens

Full name:

transglutaminase 3

Synonyms:

TGE, UHS2, protein-glutamine gamma-glutamyltransferase E, E polypeptide, protein-glutamine-gamma-glutamyltransferase, TG(E), TGase E, TGase-3, transglutaminase E

Genomic Location:

Chr 20: 2224675-2269725

Description:

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two poly...

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Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

OCT1_07 ,  TTTGCAC_MIR19A_MIR19B ,  TGANTCA_AP1_C ,  RYTTCCTG_ETS2_B ,  TATAAA_TATA_01 ,  NKX62_Q2 ,  RNGTGGGC_UNKNOWN ,  BACH1_01 ,  TAATTA_CHX10_01 ,  CEBP_C ,  TATA_01 ,  IK1_01 ,  TGACAGNY_MEIS1_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-19

Cytogenetic Map:

20p13

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