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QuickView for TGF-beta 2 (gene)


Gene Symbol:
Tgfbr2 Rattus norvegicus Rattus norvegicus
Full name:
transforming growth factor, beta receptor 2
Synonyms:
TGF-beta 2, Tgfbr2T, TGF-beta receptor type-2, TGF-beta receptor type II, TGF-beta type II receptor, TGFR-2, tbetaR-II, transforming growth factor beta receptor type II, transforming growth factor, beta receptor II, transforming growth factor, beta receptor IIT, transforming growth factor-b type II receptor, transforming growth factor-beta type II receptor
Genomic Location:
Chr 8: 120593595-120680453
Description:
receptor for TGF-beta; may play a role in lung maturation and response to hypoxia
Orthologs:
Homo sapiens Mus musculus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:


Transcripts Names
NM_031132
XM_001077015
XM_008766690
Protein Names
P38438



GO Molecular Function

transforming growth factor beta binding | cytokine binding | kinase binding | transforming growth factor beta-activated receptor activity | cation binding | protein kinase binding | transmembrane signaling receptor activity | enzyme binding | protein-containing complex binding | ribonucleotide binding | transforming growth factor beta receptor binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | cytokine receptor binding | protein serine/threonine kinase activity | growth factor binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | activin binding | signaling receptor activity | purine nucleotide binding | identical protein binding | protein heterodimerization activity | transforming growth factor beta receptor activity, type II | ion binding | organic cyclic compound binding | type I transforming growth factor beta receptor binding | purine ribonucleoside triphosphate binding | mitogen-activated protein kinase kinase kinase binding | protein binding | protein homodimerization activity | transmembrane receptor protein serine/threonine kinase activity | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | glycosaminoglycan binding | transferase activity | type III transforming growth factor beta receptor binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | SMAD binding | metal ion binding | heterocyclic compound binding | small molecule binding

GO Biological Process

positive regulation of smooth muscle cell proliferation | response to extracellular stimulus | brain development | Notch signaling pathway | positive regulation of locomotion | response to nutrient levels | growth plate cartilage chondrocyte differentiation | chondrocyte development | cranial skeletal system development | regulation of localization | morphogenesis of an epithelium | peptidyl-amino acid modification | eye development | epithelial cell apoptotic process | establishment of localization | regulation of immune system process | response to hormone | myeloid cell differentiation | negative regulation of cellular process | positive regulation of developmental process | positive regulation of lymphocyte activation | bone development | regulation of heart growth | cell differentiation | regulation of T cell differentiation | respiratory tube development | negative regulation of organ growth | nervous system development | response to drug | transforming growth factor beta-activated receptor activity | organ growth | endochondral bone morphogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | mesenchyme development | blood vessel morphogenesis | positive regulation of T cell differentiation | regulation of cardiac muscle cell proliferation | pattern specification process | cellular process | negative regulation of muscle organ development | regulation of cell motility | localization | epithelial tube morphogenesis | heart morphogenesis | developmental growth | cell proliferation involved in endocardial cushion morphogenesis | positive regulation of T cell tolerance induction | negative regulation of developmental growth | positive regulation of reactive oxygen species metabolic process | determination of left/right symmetry | positive regulation of epithelial to mesenchymal transition | female pregnancy | immune system development | regulation of striated muscle tissue development | positive regulation of protein kinase activity | macromolecule localization | bronchus development | response to hypoxia | response to growth factor | positive regulation of catalytic activity | myeloid dendritic cell differentiation | positive regulation of nitrogen compound metabolic process | growth plate cartilage development | pathway-restricted SMAD protein phosphorylation | tissue development | regulation of cell differentiation | ventricular septum morphogenesis | regeneration | growth plate cartilage chondrocyte development | regulation of angiogenesis | regulation of cellular process | leukocyte activation | regulation of metabolic process | positive regulation of cellular protein metabolic process | epithelium development | response to transforming growth factor beta | positive regulation of skeletal muscle tissue regeneration | positive regulation of epithelial cell migration | mammary gland morphogenesis | head development | negative regulation of cardiac muscle tissue development | branching involved in blood vessel morphogenesis | regulation of vasculature development | response to stimulus | peptidyl-threonine phosphorylation | vasculature development | lung lobe morphogenesis | respiratory system development | positive regulation of immune system process | positive regulation of protein metabolic process | endocardial cushion fusion | regulation of CD4-positive, alpha-beta T cell activation | determination of heart left/right asymmetry | gland morphogenesis | response to stress | positive regulation of lymphocyte proliferation | regulation of cell proliferation | activin receptor signaling pathway | roof of mouth development | tube morphogenesis | positive regulation of cell-cell adhesion | response to glucose | protein serine/threonine kinase activity | programmed cell death | cartilage development involved in endochondral bone morphogenesis | positive regulation of cell activation | reproduction | atrioventricular valve morphogenesis | embryonic skeletal system development | response to alcohol | cardiovascular system development | cardiac ventricle morphogenesis | positive regulation of T cell activation | negative regulation of muscle tissue development | myeloid dendritic cell activation | hemopoiesis | regulation of wound healing | protein modification process | cartilage development | regulation of cell adhesion | embryo development | macromolecule modification | trachea morphogenesis | activation of protein kinase activity | regulation of lymphocyte differentiation | blood vessel development | leukocyte differentiation | chondrocyte differentiation involved in endochondral bone morphogenesis | apoptotic process | positive regulation of mononuclear cell proliferation | endocardial cushion development | system development | chondrocyte differentiation | positive regulation of NK T cell differentiation | response to oxygen levels | positive regulation of response to wounding | nitrogen compound metabolic process | reproductive process | negative regulation of growth | multicellular organism development | positive regulation of lymphocyte differentiation | phosphorus metabolic process | mammary gland development | regulation of catalytic activity | embryonic hemopoiesis | regulation of phosphorylation | regulation of tolerance induction to self antigen | wound healing | regulation of T cell activation | determination of bilateral symmetry | positive regulation of alpha-beta T cell differentiation | regulation of gene expression | positive regulation of B cell tolerance induction | outflow tract morphogenesis | organic substance transport | response to lipid | endocardial cushion morphogenesis | myeloid leukocyte differentiation | embryonic heart tube morphogenesis | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | positive regulation of alpha-beta T cell proliferation | regulation of lymphocyte activation | positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation | animal organ morphogenesis | regulation of tolerance induction | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | response to cholesterol | bone growth | superior endocardial cushion morphogenesis | vesicle-mediated transport | regulation of cellular component movement | response to nutrient | positive regulation of cell differentiation | positive regulation of CD4-positive, alpha-beta T cell proliferation | positive regulation of cell migration | cell proliferation | transforming growth factor beta receptor activity, type II | lens fiber cell apoptotic process | regulation of cellular protein metabolic process | positive regulation of T cell proliferation | angiogenesis | mesenchyme morphogenesis | phosphorylation | cardiac septum morphogenesis | digestive tract development | heart looping | establishment of RNA localization | protein phosphorylation | phosphate-containing compound metabolic process | sensory organ development | positive regulation of tolerance induction to self antigen | trachea formation | response to estrogen | chordate embryonic development | animal organ formation | negative regulation of cardiac muscle cell proliferation | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | transmembrane receptor protein serine/threonine kinase signaling pathway | skeletal system morphogenesis | regulation of alpha-beta T cell differentiation | miRNA transport | regulation of skeletal muscle tissue regeneration | regulation of protein metabolic process | vasculogenesis | negative regulation of striated muscle tissue development | heart development | positive regulation of cell proliferation | response to monosaccharide | regulation of protein phosphorylation | bone morphogenesis | regulation of locomotion | embryo development ending in birth or egg hatching | chondrocyte hypertrophy | common-partner SMAD protein phosphorylation | embryonic morphogenesis | positive regulation of molecular function | cellular response to transforming growth factor beta stimulus | secondary palate development | embryonic organ morphogenesis | embryonic cranial skeleton morphogenesis | tricuspid valve development | heart valve development | ventricular septum development | protein metabolic process | transmembrane receptor protein serine/threonine kinase activity | cardiac ventricle development | positive regulation of protein modification process | regulation of growth | response to organic substance | gland development | regulation of cardiac muscle tissue development | tissue morphogenesis | digestive system development | regulation of hemopoiesis | branching morphogenesis of an epithelial tube | regulation of kinase activity | response to wounding | response to mechanical stimulus | regulation of animal organ morphogenesis | import into cell | embryonic heart tube development | anatomical structure development | developmental growth involved in morphogenesis | nucleobase-containing compound transport | cell surface receptor signaling pathway | embryonic skeletal system morphogenesis | metabolic process | dendritic cell differentiation | positive regulation of leukocyte activation | regulation of T cell tolerance induction | embryonic organ development | endocytosis | cell adhesion | trachea development | protein kinase activity | heart valve morphogenesis | organic substance metabolic process | connective tissue development | cell death | animal organ development | regulation of cell activation | regulation of epithelial to mesenchymal transition involved in endocardial cushion formation | positive regulation of kinase activity | regulation of heart morphogenesis | regulation of phosphate metabolic process | positive regulation of wound healing | cell-cell adhesion | atrioventricular valve development | cell activation | lung development | RNA transport | morphogenesis of a branching epithelium | camera-type eye development | transforming growth factor beta receptor signaling pathway | smoothened signaling pathway | anatomical structure formation involved in morphogenesis | regulation of epithelial cell migration | regulation of response to wounding | chondrocyte development involved in endochondral bone morphogenesis | regulation of NK T cell differentiation | positive regulation of developmental growth | signaling | positive regulation of growth | response to organic cyclic compound | cell development | regulation of developmental growth | regulation of T cell proliferation | positive regulation of phosphorylation | cellular protein metabolic process | morphogenesis of a branching structure | anatomical structure morphogenesis | regulation of organ growth | regulation of developmental process | receptor-mediated endocytosis | kinase activity | regulation of mesenchymal cell proliferation | developmental process | positive regulation of alpha-beta T cell activation | peptidyl-serine phosphorylation | cardiac septum development | cellular protein modification process | bronchus morphogenesis | tube development | regulation of reactive oxygen species metabolic process | membranous septum morphogenesis | negative regulation of cell proliferation | regulation of cell-cell adhesion | developmental cell growth | positive regulation of mesenchymal cell proliferation | positive regulation of tolerance induction | lung morphogenesis | regulation of epithelial to mesenchymal transition | cardiac chamber development | embryo implantation | central nervous system development | cell adhesion involved in heart morphogenesis | cell-cell adhesion via plasma-membrane adhesion molecules | in utero embryonic development | positive regulation of metabolic process | growth plate cartilage chondrocyte growth | skeletal system development | tricuspid valve morphogenesis | gastrulation | immune system process | lung lobe development | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of smooth muscle cell proliferation | positive regulation of cell motility | response to carbohydrate | response to steroid hormone | positive regulation of CD4-positive, alpha-beta T cell activation | inferior endocardial cushion morphogenesis | circulatory system development | aging | endochondral bone growth | RNA localization | positive regulation of leukocyte cell-cell adhesion | positive regulation of angiogenesis | positive regulation of cardiac epithelial to mesenchymal transition | lens development in camera-type eye | cardiac left ventricle morphogenesis | signal transduction | animal organ regeneration | outflow tract septum morphogenesis | cellular response to growth factor stimulus | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | catalytic complex | transforming growth factor beta receptor complex | protein kinase complex | cell | plasma membrane protein complex | intrinsic component of membrane | external side of plasma membrane | cytoplasm | receptor complex | membrane microdomain | protein-containing complex | plasma membrane | membrane raft | transferase complex | integral component of plasma membrane | serine/threonine protein kinase complex | activin receptor complex | cell periphery | plasma membrane raft | cytosol | cell surface | intracellular | caveola | membrane | intrinsic component of plasma membrane