QuickView for TGF1a (gene)
- Gene Symbol:
- MAP3K7
Homo sapiens - Full name:
- mitogen-activated protein kinase kinase kinase 7
- Synonyms:
- CSCF, FMD2, MEKK7, TAK1, TGF1a, mitogen-activated protein kinase kinase kinase 7, TGF-beta activated kinase 1, transforming growth factor-beta-activated kinase 1
- Genomic Location:
- Chr 6: 91282074-91353628
- Description:
-
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
6q15
GO Molecular Function
kinase binding | cation binding | protein kinase binding | magnesium ion binding | receptor tyrosine kinase binding | enzyme binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | MAP kinase kinase kinase activity | purine nucleotide binding | identical protein binding | scaffold protein binding | ion binding | organic cyclic compound binding | protein tyrosine kinase binding | purine ribonucleoside triphosphate binding | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
positive regulation of immune response | protein modification by small protein removal | RNA metabolic process | regulation of JUN kinase activity | nucleotide-binding oligomerization domain containing signaling pathway | regulation of T cell mediated immunity | response to cytokine | response to interleukin-1 | immune response-regulating signaling pathway | intracellular signal transduction | proteolysis | positive regulation of DNA-binding transcription factor activity | peptidyl-amino acid modification | immune response-regulating cell surface receptor signaling pathway | regulation of autophagy | regulation of immune system process | regulation of MAP kinase activity | histone modification | immune response-activating cell surface receptor signaling pathway | T cell receptor signaling pathway | histone H3 acetylation | positive regulation of phosphate metabolic process | innate immune response activating cell surface receptor signaling pathway | innate immune response-activating signal transduction | cellular process | toll-like receptor signaling pathway | chromatin organization | positive regulation of immune effector process | positive regulation of adaptive immune response | I-kappaB phosphorylation | positive regulation of protein kinase activity | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | interspecies interaction between organisms | regulation of immune response | regulation of cellular process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | positive regulation of T cell cytokine production | cellular aromatic compound metabolic process | cellular component organization | protein deubiquitination | MAPK cascade | response to transforming growth factor beta | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | positive regulation of NIK/NF-kappaB signaling | JNK cascade | positive regulation of innate immune response | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | response to stress | cellular nitrogen compound biosynthetic process | protein serine/threonine kinase activity | programmed cell death | activation of innate immune response | peptidyl-lysine acetylation | cellular nitrogen compound metabolic process | immune response-activating signal transduction | regulation of macroautophagy | positive regulation of protein serine/threonine kinase activity | protein modification process | cellular biosynthetic process | macromolecule modification | cell-cell signaling | activation of protein kinase activity | cell surface receptor signaling pathway involved in cell-cell signaling | stress-activated protein kinase signaling cascade | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | apoptotic process | nitrogen compound metabolic process | regulation of signal transduction | pattern recognition receptor signaling pathway | Wnt signaling pathway | protein acetylation | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | anoikis | regulation of gene expression | cellular response to stress | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | MAP kinase kinase kinase activity | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | positive regulation of JNK cascade | interleukin-1-mediated signaling pathway | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | Fc-epsilon receptor signaling pathway | regulation of T cell cytokine production | non-canonical Wnt signaling pathway | cellular response to cytokine stimulus | histone acetylation | internal peptidyl-lysine acetylation | biosynthetic process | stress-activated MAPK cascade | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | phosphorylation | activation of NF-kappaB-inducing kinase activity | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | transmembrane receptor protein serine/threonine kinase signaling pathway | activation of MAPKK activity | regulation of cytokine production involved in immune response | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | regulation of RNA metabolic process | viral process | positive regulation of molecular function | cellular response to transforming growth factor beta stimulus | activation of MAPK activity | Wnt signaling pathway, calcium modulating pathway | activation of immune response | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | protein metabolic process | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | regulation of kinase activity | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | cell surface receptor signaling pathway | metabolic process | regulation of adaptive immune response | regulation of RNA biosynthetic process | positive regulation of cytokine production involved in immune response | peptidyl-lysine modification | nucleobase-containing compound metabolic process | protein kinase activity | organic substance metabolic process | cell death | gene expression | positive regulation of NF-kappaB transcription factor activity | positive regulation of kinase activity | protein modification by small protein conjugation or removal | regulation of phosphate metabolic process | antigen receptor-mediated signaling pathway | positive regulation of autophagy | transcription, DNA-templated | positive regulation of cytokine production | positive regulation of macroautophagy | regulation of JNK cascade | positive regulation of MAPK cascade | positive regulation of T cell mediated immunity | intracellular receptor signaling pathway | transforming growth factor beta receptor signaling pathway | regulation of stress-activated MAPK cascade | regulation of cell communication | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | covalent chromatin modification | regulation of transcription, DNA-templated | I-kappaB kinase/NF-kappaB signaling | internal protein amino acid acetylation | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | cellular macromolecule biosynthetic process | positive regulation of MAP kinase activity | kinase activity | organelle organization | Fc receptor signaling pathway | cellular response to interleukin-1 | cellular protein modification process | positive regulation of interleukin-2 production | MyD88-dependent toll-like receptor signaling pathway | stimulatory C-type lectin receptor signaling pathway | NIK/NF-kappaB signaling | heterocycle metabolic process | positive regulation of JUN kinase activity | positive regulation of metabolic process | chromosome organization | immune system process | cellular metabolic process | cellular response to organic substance | regulation of I-kappaB kinase/NF-kappaB signaling | positive regulation of signaling | signal transduction | regulation of signaling | cellular response to growth factor stimulus | macromolecule metabolic process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | catalytic complex | organelle membrane | cytoplasmic vesicle | protein kinase complex | cell | nuclear lumen | histone acetyltransferase complex | cytoplasm | intracellular organelle | endosome membrane | IkappaB kinase complex | protein-containing complex | endomembrane system | nucleoplasm | plasma membrane | vesicle | transferase complex | endosome | serine/threonine protein kinase complex | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | protein acetyltransferase complex | cytosol | intracellular vesicle | intracellular | membrane | Ada2/Gcn5/Ada3 transcription activator complex
