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QuickView for TGF2H5 (gene)


Gene Symbol:
GTF2H5 Homo sapiens Homo sapiens
Full name:
general transcription factor IIH subunit 5
Synonyms:
C6orf175, TFB5, TFIIH, TGF2H5, TTD, TTD-A, TTD3, TTDA, bA120J8.2, general transcription factor IIH subunit 5, TFB5 ortholog, TFIIH basal transcription factor complex TTD-A subunit, TFIIH basal transcription factor complex TTDA subunit, general transcription factor IIH, polypeptide 5
Genomic Location:
Chr 6: 158511489-158533375
Description:
This gene encodes a subunit of transcription/repair factor TFIIH, which functions in gene transcription and DNA repair. This protein stimulates ERCC3/XPB ATPase activity to trigger DNA opening during DNA repair, and is implicated in regulating cellular levels of TFIIH. Mutations in this gene result in trichothiodystrophy, complementation group A.
Orthologs:
Mus musculus Rattus norvegicus C. elegans Macaca mulatta Bos taurus Canis lupus familiaris Pan troglodytes Danio rerio Gallus gallus
External Links:
Entrez Gene
Cytogenetic Map:
chr 6
6q25.3


Transcripts Names
NM_207118
XM_017010862
Protein Names
Q0P5V8
Q6ZYL4



GO Molecular Function

sequence-specific DNA binding | nucleic acid binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | protein binding | double-stranded DNA binding | rDNA binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | DNA-templated transcription, initiation | response to radiation | RNA processing | positive regulation of cellular component organization | transcription initiation from RNA polymerase I promoter | cellular process | 7-methylguanosine mRNA capping | global genome nucleotide-excision repair | ribosome biogenesis | regulation of cellular process | regulation of metabolic process | regulation of protein complex assembly | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | response to stimulus | response to stress | transcription by RNA polymerase I | cellular nitrogen compound biosynthetic process | ncRNA processing | protein-DNA complex assembly | cellular nitrogen compound metabolic process | nucleic acid phosphodiester bond hydrolysis | cellular component assembly | mRNA metabolic process | cellular biosynthetic process | DNA repair | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | cellular response to DNA damage stimulus | nucleotide-excision repair, DNA incision, 5'-to lesion | regulation of gene expression | cellular response to stress | cellular response to radiation | regulation of nitrogen compound metabolic process | positive regulation of protein complex assembly | cellular response to gamma radiation | biosynthetic process | aromatic compound biosynthetic process | cellular protein-containing complex assembly | nucleotide-excision repair, preincision complex stabilization | rRNA metabolic process | transcription elongation from RNA polymerase II promoter | response to gamma radiation | regulation of cellular metabolic process | regulation of RNA metabolic process | rRNA processing | DNA-templated transcription, termination | protein-containing complex assembly | DNA metabolic process | nucleotide-excision repair, DNA incision | metabolic process | nucleotide-excision repair | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | positive regulation of cellular component biogenesis | organic substance metabolic process | gene expression | cellular response to ionizing radiation | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | transcription-coupled nucleotide-excision repair | regulation of transcription, DNA-templated | transcription elongation from RNA polymerase I promoter | cellular macromolecule biosynthetic process | 7-methylguanosine RNA capping | ncRNA metabolic process | heterocycle metabolic process | ribonucleoprotein complex biogenesis | cellular metabolic process | mRNA processing | regulation of cellular component organization | response to ionizing radiation | termination of RNA polymerase I transcription | nucleotide-excision repair, preincision complex assembly | macromolecule metabolic process | DNA-templated transcription, elongation

GO Cellular Component

nuclear transcription factor complex | intracellular membrane-bounded organelle | catalytic complex | RNA polymerase II transcription factor complex | cell | nuclear lumen | transcription factor complex | nucleolus | intracellular organelle | protein-containing complex | nucleoplasm | transferase complex | membrane-bounded organelle | nucleus | organelle | nuclear DNA-directed RNA polymerase complex | transcription factor TFIID complex | RNA polymerase complex | membrane-enclosed lumen | core TFIIH complex | intracellular | RNA polymerase II, holoenzyme