QuickView for TGFA (gene)

Gene Symbol:

TGFA Homo sapiens

Full name:

transforming growth factor alpha

Synonyms:

TFGA, protransforming growth factor alpha, TGF-alpha

Genomic Location:

Chr 2: 70527924-70634613

Description:

This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involv...

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This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Gallus gallus ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TAATGTG_MIR323 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  AATGTGA_MIR23A_MIR23B ,  TATTATA_MIR374

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-374

Cytogenetic Map:

2p13.3

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