QuickView for TGFB1I4 (gene)

Gene Symbol:

TSC22D1 Homo sapiens

Full name:

TSC22 domain family member 1

Synonyms:

Ptg-2, TGFB1I4, TSC22, TSC22 domain family protein 1, TGFB-stimulated clone 22 homolog, TGFbeta-stimulated clone 22, cerebral protein 2, regulatory protein TSC-22, transcriptional regulator TSC-22, transforming growth factor beta-1-induced transcript 4 protein, transforming growth factor beta-stimulated protein TSC-22

Genomic Location:

Chr 13: 43905658-44048701

Description:

This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer...

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This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CRGAARNNNNCGA_UNKNOWN ,  GATTGGY_NFY_Q6_01 ,  HNF4ALPHA_Q6 ,  CEBPA_01 ,  TTANTCA_UNKNOWN ,  P53_DECAMER_Q2 ,  RSRFC4_01 ,  EFC_Q6 ,  MIF1_01 ,  YTATTTTNR_MEF2_02 ,  E4BP4_01 ,  YGACNNYACAR_UNKNOWN ,  RSRFC4_Q2 ,  CEBP_Q2_01 ,  GTACTGT_MIR101 ,  CYTAGCAAY_UNKNOWN ,  CTAWWWATA_RSRFC4_Q2 ,  TTAYRTAA_E4BP4_01 ,  OSF2_Q6 ,  MEF2_02 ,  TGAYRTCA_ATF3_Q6 ,  TATAAA_TATA_01 ,  CEBP_Q2 ,  CATTTCA_MIR203 ,  MEF2_01 ,  P53_02 ,  CDX2_Q5 ,  CAGGTG_E12_Q6 ,  TST1_01 ,  CREBP1_01 ,  NFY_01 ,  GATA6_01 ,  GCM_Q2 ,  TGTYNNNNNRGCARM_UNKNOWN ,  HMEF2_Q6 ,  CAGTCAC_MIR134 ,  RNGTGGGC_UNKNOWN ,  HMGIY_Q6 ,  GTGCCTT_MIR506 ,  HLF_01 ,  AP2REP_01 ,  CEBP_C ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  MEF2_03 ,  WTTGKCTG_UNKNOWN ,  IK3_01 ,  TATA_01 ,  CP2_02 ,  CTGCAGY_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  TBP_01 ,  YWATTWNNRGCT_UNKNOWN ,  RCGCANGCGY_NRF1_Q6 ,  AACTTT_UNKNOWN ,  TGACATY_UNKNOWN ,  CRX_Q4 ,  ACCTGTTG_UNKNOWN ,  ATGAAGG_MIR205 ,  MYB_Q3 ,  MEF2_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-134 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-542-3p ,  Predicted Gene Targets for miR-124a

Cytogenetic Map:

13q14.11

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