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QuickView for TGFB2 (gene)


Gene Symbol:
TGFB2 Homo sapiens Homo sapiens
Full name:
transforming growth factor beta 2
Synonyms:
G-TSF, LDS4, TGF-beta2, transforming growth factor beta-2, BSC-1 cell growth inhibitor, cetermin, glioblastoma-derived T-cell suppressor factor, polyergin, prepro-transforming growth factor beta-2
Genomic Location:
Chr 1: 216586491-216681596
Description:
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-a...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 1
1q41





GO Molecular Function

peptide binding | amyloid-beta binding | transforming growth factor beta receptor binding | signaling receptor binding | cytokine receptor binding | molecular function regulator | amide binding | identical protein binding | protein heterodimerization activity | protein binding | protein homodimerization activity | receptor regulator activity | protein dimerization activity | growth factor activity | receptor ligand activity | cytokine activity | type III transforming growth factor beta receptor binding | type II transforming growth factor beta receptor binding

GO Biological Process

positive regulation of immune response | positive regulation of heart contraction | limb development | molting cycle | SMAD protein signal transduction | cell morphogenesis | ventricular cardiac muscle tissue morphogenesis | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of dephosphorylation | negative regulation of immune system process | negative regulation of macrophage cytokine production | positive regulation of blood circulation | exocytosis | epidermis morphogenesis | extracellular structure organization | positive regulation of cellular component organization | cell motility | pharyngeal system development | cranial skeletal system development | developmental process involved in reproduction | muscle tissue development | positive regulation of apoptotic process | regulation of integrin biosynthetic process | regulation of localization | heart trabecula morphogenesis | catechol-containing compound metabolic process | morphogenesis of an epithelium | gonad development | regulation of programmed cell death | eye development | establishment of localization | regulation of immune system process | response to hormone | platelet degranulation | negative regulation of cellular process | positive regulation of developmental process | regulation of phosphatase activity | embryonic appendage morphogenesis | cell differentiation | nervous system development | epithelial to mesenchymal transition | response to drug | organ growth | neurogenesis | pulmonary valve development | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | generation of neurons | positive regulation of protein secretion | mesenchyme development | salivary gland morphogenesis | cardiac atrium morphogenesis | phenol-containing compound metabolic process | blood vessel morphogenesis | regulation of neuron death | neural retina development | positive regulation of cellular biosynthetic process | cellular process | secretion | ascending aorta morphogenesis | regulation of cell motility | localization | epithelial tube morphogenesis | extrinsic apoptotic signaling pathway | limb morphogenesis | odontogenesis | heart morphogenesis | negative regulation of signaling | developmental growth | neuron development | reproductive system development | response to progesterone | positive regulation of timing of catagen | positive regulation of epithelial to mesenchymal transition | positive regulation of pathway-restricted SMAD protein phosphorylation | immune system development | multicellular organismal reproductive process | positive regulation of protein kinase activity | response to hypoxia | negative regulation of alkaline phosphatase activity | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | positive regulation of cell division | granulocyte chemotaxis | pathway-restricted SMAD protein phosphorylation | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | muscle structure development | ventricular septum morphogenesis | regulation of angiogenesis | regulation of immune response | regulation of cellular process | positive regulation of cell growth | regulation of apoptotic process | regulation of metabolic process | gliogenesis | positive regulation of stress-activated MAPK cascade | organic cyclic compound metabolic process | trabecula morphogenesis | positive regulation of cellular protein metabolic process | positive regulation of cell adhesion mediated by integrin | negative regulation of phosphatase activity | positive regulation of hair cycle | epithelium development | cellular aromatic compound metabolic process | cellular component organization | ventricular trabecula myocardium morphogenesis | response to transforming growth factor beta | regulation of cell division | urogenital system development | positive regulation of epithelial cell migration | development of primary sexual characteristics | regulation of peptide secretion | positive regulation of stress-activated protein kinase signaling cascade | muscle organ morphogenesis | regulation of vasculature development | response to stimulus | cardiac right ventricle morphogenesis | vasculature development | negative regulation of epithelial to mesenchymal transition | embryonic limb morphogenesis | neutrophil chemotaxis | positive regulation of cardioblast differentiation | embryonic epithelial tube formation | positive regulation of immune system process | positive regulation of protein metabolic process | endocardial cushion fusion | positive regulation of phosphatidylinositol 3-kinase signaling | gland morphogenesis | response to stress | regulation of cell proliferation | ovulation cycle | roof of mouth development | negative regulation of angiogenesis | cardiac muscle cell proliferation | tube morphogenesis | regulation of blood circulation | cardiac muscle tissue development | muscle tissue morphogenesis | programmed cell death | supramolecular fiber organization | epithelial tube formation | reproduction | atrioventricular valve morphogenesis | secretion by cell | cardiovascular system development | cardiac ventricle morphogenesis | rhythmic process | extracellular matrix organization | catecholamine biosynthetic process | regulation of protein transport | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | regulation of apoptotic process involved in outflow tract morphogenesis | hemopoiesis | protein modification process | positive regulation of hair follicle development | regulation of peptide transport | regulation of cell adhesion | cellular biosynthetic process | kidney development | embryo development | heart growth | macromolecule modification | cell-cell signaling | dopamine metabolic process | cell chemotaxis | activation of protein kinase activity | molecular function regulator | blood vessel development | leukocyte migration | pulmonary valve morphogenesis | regulation of nucleic acid-templated transcription | somatic stem cell division | positive regulation of peptide secretion | regulation of cellular response to stress | locomotion | organic hydroxy compound metabolic process | apoptotic process | endocardial cushion development | system development | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | negative regulation of growth | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | cell migration | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | regulation of phosphorylation | regulation of ossification | hair follicle morphogenesis | embryonic digestive tract development | wound healing | cardiac epithelial to mesenchymal transition | artery development | positive regulation of cell cycle | regulation of small GTPase mediated signal transduction | regulation of gene expression | positive regulation of secretion | neural tube closure | outflow tract morphogenesis | response to ketone | response to lipid | cell cycle | endocardial cushion morphogenesis | regulation of epidermis development | stem cell division | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation | animal organ morphogenesis | regulation of pri-miRNA transcription by RNA polymerase II | positive regulation of Notch signaling pathway | regulation of nitrogen compound metabolic process | regulation of cell migration | glial cell migration | regulation of Notch signaling pathway | enzyme linked receptor protein signaling pathway | regulation of timing of catagen | cardiac atrium development | positive regulation of intracellular signal transduction | neural tube formation | cardiocyte differentiation | regulation of hair follicle development | vesicle-mediated transport | regulation of cellular component movement | regulation of transcription by RNA polymerase II | dopamine biosynthetic process | positive regulation of cell differentiation | stem cell differentiation | positive regulation of cell migration | cell proliferation | pharyngeal arch artery morphogenesis | biosynthetic process | cell division | neural tube development | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | negative regulation of immune response | positive regulation of ossification | angiogenesis | mesenchyme morphogenesis | regulation of cell adhesion mediated by integrin | phosphorylation | positive regulation of pri-miRNA transcription by RNA polymerase II | cardiac septum morphogenesis | regulated exocytosis | digestive tract development | regulation of complement-dependent cytotoxicity | positive regulation of neuron death | epidermis development | septum primum development | skin development | regulation of heart contraction | protein phosphorylation | uterine wall breakdown | phosphate-containing compound metabolic process | sensory organ development | ovulation cycle process | chordate embryonic development | striated muscle tissue development | cardiac muscle tissue morphogenesis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of neuron apoptotic process | semi-lunar valve development | regulation of cytokine production involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | inner ear development | leukocyte chemotaxis | heart development | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | regulation of stem cell differentiation | renal system development | positive regulation of transport | negative regulation of cell growth | apoptotic signaling pathway | embryonic morphogenesis | cardiac muscle tissue growth | drug metabolic process | positive regulation of molecular function | cellular response to transforming growth factor beta stimulus | secondary palate development | neuron differentiation | multicellular organism reproduction | regulation of signaling receptor activity | receptor regulator activity | development of primary male sexual characteristics | heart valve development | ventricular septum development | negative regulation of epithelial cell proliferation | protein metabolic process | regulation of establishment of protein localization | cardiac ventricle development | positive regulation of protein modification process | regulation of growth | hair cycle | response to organic substance | gland development | tissue morphogenesis | artery morphogenesis | digestive system development | cell cycle arrest | retina development in camera-type eye | catecholamine metabolic process | regulation of kinase activity | male sex differentiation | response to wounding | regulation of animal organ morphogenesis | negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | ventricular cardiac muscle tissue development | positive regulation of neuron apoptotic process | anatomical structure development | cell surface receptor signaling pathway | aorta development | growth factor activity | metabolic process | mesenchymal cell differentiation | regulation of RNA biosynthetic process | embryonic organ development | male gonad development | ear development | atrial septum primum morphogenesis | hair cycle process | regulation of secretion | positive regulation of cell death | cell adhesion | morphogenesis of embryonic epithelium | receptor ligand activity | cytokine activity | heart valve morphogenesis | organic substance metabolic process | cell death | negative regulation of gene expression | animal organ development | negative regulation of small GTPase mediated signal transduction | regulation of protein secretion | regulation of epithelial to mesenchymal transition involved in endocardial cushion formation | negative regulation of Ras protein signal transduction | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of heart morphogenesis | skin epidermis development | regulation of phosphate metabolic process | regulation of transforming growth factor beta2 production | cell-cell adhesion | atrioventricular valve development | positive regulation of stem cell differentiation | positive regulation of MAPK cascade | aorta morphogenesis | atrial septum development | positive regulation of protein transport | camera-type eye development | transforming growth factor beta receptor signaling pathway | anatomical structure formation involved in morphogenesis | uterus development | negative regulation of cell cycle | regulation of epithelial cell migration | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of molecular function | muscle cell proliferation | negative regulation of signal transduction | signaling | positive regulation of growth | regulation of transcription, DNA-templated | response to organic cyclic compound | cell development | collagen fibril organization | regulation of epithelial cell proliferation | positive regulation of phosphorylation | cellular protein metabolic process | cardioblast differentiation | regulation of cytokine production | regulation of Ras protein signal transduction | anatomical structure morphogenesis | reproductive structure development | regulation of developmental process | developmental process | regulation of cell growth | cardiac septum development | cellular protein modification process | tube development | regulation of transport | positive regulation of transcription, DNA-templated | membranous septum morphogenesis | negative regulation of cell proliferation | regulation of hair cycle | atrial septum morphogenesis | negative regulation of vasculature development | positive regulation of nucleic acid-templated transcription | tube closure | negative regulation of dephosphorylation | positive regulation of transcription by RNA polymerase II | regulation of epithelial to mesenchymal transition | positive regulation of epidermis development | cardiac chamber development | regulation of apoptotic process involved in development | negative regulation of hydrolase activity | tube formation | cell adhesion involved in heart morphogenesis | cell-cell adhesion via plasma-membrane adhesion molecules | positive regulation of metabolic process | skeletal system development | regulation of cardioblast differentiation | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of protein localization | exocrine system development | regulation of cell death | sex differentiation | positive regulation of cell motility | salivary gland development | response to steroid hormone | neutrophil migration | circulatory system development | chemotaxis | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of cardiac epithelial to mesenchymal transition | positive regulation of integrin biosynthetic process | muscle organ development | substantia propria of cornea development | positive regulation of signaling | hair follicle development | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | regulation of pathway-restricted SMAD protein phosphorylation | positive regulation of gene expression | outflow tract septum morphogenesis | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | cell-cell junction organization | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | neuron projection | extracellular matrix | somatodendritic compartment | cytoplasmic vesicle | cell body | cell | neuronal cell body | cytoplasmic vesicle lumen | cytoplasm | collagen-containing extracellular matrix | intracellular organelle | platelet alpha granule | cell projection | secretory vesicle | endomembrane system | vesicle | extracellular region | membrane-bounded organelle | organelle | extracellular space | axon | membrane-enclosed lumen | secretory granule lumen | intracellular vesicle | intracellular | platelet alpha granule lumen | vesicle lumen