QuickView for THRAL (gene)

Gene Symbol:

NR1D1 Homo sapiens

Full name:

nuclear receptor subfamily 1 group D member 1

Synonyms:

EAR1, THRA1, THRAL, ear-1, hRev, nuclear receptor subfamily 1 group D member 1, Rev-ErbAalpha, V-erbA-related protein 1, nuclear receptor Rev-ErbA-alpha, rev-erbA-alpha

Genomic Location:

Chr 17: 35502567-35510499

Description:

This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-li...

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This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  FOXO1_02 ,  GATTGGY_NFY_Q6_01 ,  TFIIA_Q6 ,  TGANTCA_AP1_C ,  OCT1_B ,  ETS_Q4 ,  TCANNTGAY_SREBP1_01 ,  RYTTCCTG_ETS2_B ,  ARNT_01 ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  E4BP4_01 ,  TEL2_Q6 ,  VDR_Q6 ,  AP1_Q6 ,  ARNT_02 ,  TAAYNRNNTCC_UNKNOWN ,  SREBP1_Q6 ,  CTCNANGTGNY_UNKNOWN ,  MYCMAX_B ,  TTAYRTAA_E4BP4_01 ,  OCT_C ,  COMP1_01 ,  GGGAGGRR_MAZ_Q6 ,  MYCMAX_02 ,  STAT3_02 ,  DBP_Q6 ,  SREBP1_01 ,  FOXO3_01 ,  CAGGTA_AREB6_01 ,  ETS2_B ,  TGCGCANK_UNKNOWN ,  GAGCTGG_MIR337 ,  HNF3_Q6 ,  SP3_Q3 ,  BACH2_01 ,  GGGCGGR_SP1_Q6 ,  CREBP1_01 ,  USF_C ,  AP1_Q2_01 ,  OCT1_03 ,  HIF1_Q5 ,  YTTCCNNNGGAMR_UNKNOWN ,  ACTAYRNNNCCCR_UNKNOWN ,  HFH4_01 ,  TGTTTGY_HNF3_Q6 ,  TGTYNNNNNRGCARM_UNKNOWN ,  PAX8_B ,  NRF2_Q4 ,  TCTCTCC_MIR185 ,  RNGTGGGC_UNKNOWN ,  HLF_01 ,  NMYC_01 ,  BACH1_01 ,  ELK1_01 ,  TTGTTT_FOXO4_01 ,  CEBP_C ,  WTTGKCTG_UNKNOWN ,  CP2_02 ,  SMAD4_Q6 ,  CTGCAGY_UNKNOWN ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  CTTTGT_LEF1_Q2 ,  RCGCANGCGY_NRF1_Q6 ,  ER_Q6_01 ,  AACTTT_UNKNOWN ,  YNGTTNNNATT_UNKNOWN ,  PPAR_DR1_Q2 ,  DR4_Q2 ,  AP1_Q4_01 ,  HIF1_Q3 ,  FOXO4_02 ,  GGGTGGRR_PAX4_03 ,  TGASTMAGC_NFE2_01 ,  OLF1_01

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Cytogenetic Map:

17q21.1

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