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QuickView for THRB (gene)


Gene Symbol:
THRB Homo sapiens Homo sapiens
Full name:
thyroid hormone receptor beta
Synonyms:
C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2, thyroid hormone receptor beta, nuclear receptor subfamily 1 group A member 2, oncogene ERBA2, thyroid hormone nuclear receptor beta variant 1, thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
Genomic Location:
Chr 3: 24134709-24511317
Description:
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different funct...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Canis lupus familiaris Pan troglodytes Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 3
3p24.2





GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | nuclear receptor activity | cation binding | transcription factor activity, direct ligand regulated sequence-specific DNA binding | enzyme binding | nucleic acid binding | steroid hormone receptor activity | chromatin binding | RNA polymerase II regulatory region DNA binding | DNA binding | signaling receptor activity | sequence-specific double-stranded DNA binding | thyroid hormone binding | transcription corepressor activity | ion binding | organic cyclic compound binding | hormone binding | transcription coactivator activity | transcription regulatory region sequence-specific DNA binding | protein binding | zinc ion binding | double-stranded DNA binding | DNA-binding transcription factor activity | transcription factor binding | chromatin DNA binding | nuclear receptor transcription coactivator activity | RNA polymerase II regulatory region sequence-specific DNA binding | transition metal ion binding | transcription coregulator activity | metal ion binding | heterocyclic compound binding | thyroid hormone receptor activity

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | DNA-templated transcription, initiation | positive regulation of macromolecule biosynthetic process | retinal cone cell apoptotic process | regulation of neurogenesis | regulation of cell development | eye development | response to hormone | neuron death | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cell differentiation | respiratory tube development | type I pneumocyte differentiation | nervous system development | neurogenesis | generation of neurons | sensory perception of mechanical stimulus | hormone-mediated signaling pathway | neural retina development | positive regulation of cellular biosynthetic process | cellular process | nuclear receptor activity | neuron development | transcription factor activity, direct ligand regulated sequence-specific DNA binding | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | lung epithelium development | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | regulation of cellular process | cellular response to lipid | regulation of metabolic process | regulation of eye photoreceptor cell development | organic cyclic compound metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | negative regulation of photoreceptor cell differentiation | retinal cone cell differentiation | thyroid gland development | response to stimulus | respiratory system development | female mating behavior | cellular nitrogen compound biosynthetic process | regulation of blood circulation | programmed cell death | regulation of female receptivity | reproduction | cellular nitrogen compound metabolic process | cellular response to organic cyclic compound | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | steroid hormone receptor activity | steroid hormone mediated signaling pathway | cellular biosynthetic process | eye photoreceptor cell differentiation | retinal cell apoptotic process | regulation of nucleic acid-templated transcription | apoptotic process | cellular response to hormone stimulus | system development | nitrogen compound metabolic process | reproductive process | multicellular organism development | retina morphogenesis in camera-type eye | regulation of neuron differentiation | regulation of gene expression | response to lipid | nervous system process | positive regulation of cellular metabolic process | retinal cone cell development | animal organ morphogenesis | regulation of nitrogen compound metabolic process | neuron apoptotic process | transcription corepressor activity | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | female courtship behavior | regulation of heart contraction | endocrine system development | sensory organ development | cell communication | regulation of cellular metabolic process | eye morphogenesis | sensory perception of sound | transcription coactivator activity | regulation of RNA metabolic process | eye photoreceptor cell development | negative regulation of eye photoreceptor cell development | lung epithelial cell differentiation | neuron differentiation | multicellular organism reproduction | DNA-binding transcription factor activity | negative regulation of female receptivity | courtship behavior | response to organic substance | gland development | regulation of photoreceptor cell differentiation | retina development in camera-type eye | regulation of animal organ morphogenesis | anatomical structure development | reproductive behavior | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | nuclear receptor transcription coactivator activity | mating behavior | behavior | nucleobase-containing compound metabolic process | organic substance metabolic process | mating | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | negative regulation of neuron differentiation | gene expression | cellular response to steroid hormone stimulus | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | lung development | intracellular receptor signaling pathway | camera-type eye development | sensory perception | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | cell development | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | camera-type eye morphogenesis | regulation of nervous system development | regulation of developmental process | developmental process | lung cell differentiation | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | photoreceptor cell development | transcription coregulator activity | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | photoreceptor cell differentiation | cellular response to organic substance | response to steroid hormone | negative regulation of cell development | sexual reproduction | thyroid hormone receptor activity | camera-type eye photoreceptor cell differentiation | negative regulation of cell differentiation | signal transduction | positive regulation of gene expression | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process

GO Cellular Component

nuclear transcription factor complex | chromosome | intracellular membrane-bounded organelle | RNA polymerase II transcription factor complex | cell | nuclear lumen | transcription factor complex | intracellular organelle | nuclear body | protein-containing complex | nucleoplasm | chromatin | nuclear chromosome | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | intracellular