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Gene Symbol:
UBC Homo sapiens Homo sapiens
Full name:
ubiquitin C
Synonyms:
HMG20, polyubiquitin-C
Genomic Location:
Chr 12: 123962145-123965530
Description:
This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kin...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Schizosaccharomyces pombe Gallus gallus Bos taurus Pan troglodytes Danio rerio Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 12
12q24.31


Transcripts Names
NM_021009
XM_001132949
Protein Names
P0CG48



GO Molecular Function

enzyme binding | nucleic acid binding | ubiquitin-like protein ligase binding | protein tag | organic cyclic compound binding | protein binding | ubiquitin protein ligase binding | protease binding | heterocyclic compound binding | RNA binding

GO Biological Process

positive regulation of immune response | protein modification by small protein removal | interstrand cross-link repair | nucleotide-binding oligomerization domain containing signaling pathway | error-free translesion synthesis | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | peroxisome organization | detection of stimulus | nucleotide-excision repair, DNA damage recognition | response to cytokine | response to interleukin-1 | immune response-regulating signaling pathway | intracellular signal transduction | positive regulation of apoptotic process | proteolysis | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | translesion synthesis | establishment of localization | regulation of immune system process | regulation of transforming growth factor beta receptor signaling pathway | negative regulation of cellular process | regulation of MAP kinase activity | negative regulation of RNA biosynthetic process | positive regulation of phosphate metabolic process | membrane organization | intracellular transport | innate immune response-activating signal transduction | positive regulation of cellular biosynthetic process | cellular process | toll-like receptor signaling pathway | organic substance catabolic process | localization | proteolysis involved in cellular protein catabolic process | protein transport | negative regulation of signaling | protein targeting to peroxisome | negative regulation of nucleic acid-templated transcription | global genome nucleotide-excision repair | positive regulation of protein kinase activity | macromolecule localization | negative regulation of apoptotic process | postreplication repair | response to hypoxia | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | establishment of localization in cell | negative regulation of cellular metabolic process | interspecies interaction between organisms | regulation of mRNA stability | regulation of immune response | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular aromatic compound metabolic process | cellular component organization | protein deubiquitination | MAPK cascade | viral life cycle | response to transforming growth factor beta | response to stimulus | JNK cascade | positive regulation of innate immune response | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | endosomal transport | cellular response to hypoxia | response to stress | intracellular protein transport | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | anaphase-promoting complex-dependent catabolic process | protein-DNA complex assembly | activation of innate immune response | cellular protein catabolic process | cellular localization | cellular nitrogen compound metabolic process | proteasomal protein catabolic process | immune response-activating signal transduction | nucleic acid phosphodiester bond hydrolysis | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | cellular biosynthetic process | macromolecule modification | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | cell-cell signaling | activation of protein kinase activity | cell surface receptor signaling pathway involved in cell-cell signaling | stress-activated protein kinase signaling cascade | DNA repair | intracellular transport of virus | regulation of nucleic acid-templated transcription | negative regulation of cellular response to transforming growth factor beta stimulus | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | pattern recognition receptor signaling pathway | Wnt signaling pathway | regulation of MAPK cascade | phosphorus metabolic process | cellular response to DNA damage stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | nucleotide-excision repair, DNA incision, 5'-to lesion | regulation of gene expression | DNA biosynthetic process | organic substance transport | cellular response to stress | protein catabolic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | error-prone translesion synthesis | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | enzyme linked receptor protein signaling pathway | interleukin-1-mediated signaling pathway | peptide transport | cytokine-mediated signaling pathway | negative regulation of cellular response to growth factor stimulus | positive regulation of intracellular signal transduction | regulation of RNA stability | vesicle-mediated transport | regulation of transcription by RNA polymerase II | protein localization to organelle | cellular response to cytokine stimulus | biosynthetic process | stress-activated MAPK cascade | regulation of cellular protein metabolic process | TRIF-dependent toll-like receptor signaling pathway | aromatic compound biosynthetic process | phosphorylation | cellular protein-containing complex assembly | establishment of protein localization to peroxisome | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | regulation of RNA metabolic process | viral process | nucleotide-excision repair, DNA gap filling | regulation of cellular response to growth factor stimulus | proteasome-mediated ubiquitin-dependent protein catabolic process | positive regulation of molecular function | protein polyubiquitination | cellular response to transforming growth factor beta stimulus | activation of MAPK activity | protein-containing complex assembly | activation of immune response | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | protein metabolic process | negative regulation of transforming growth factor beta receptor signaling pathway | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | protein ubiquitination | MyD88-independent toll-like receptor signaling pathway | regulation of kinase activity | DNA metabolic process | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | cellular macromolecule catabolic process | nucleotide-excision repair, DNA incision | establishment of protein localization to organelle | cell surface receptor signaling pathway | DNA damage response, detection of DNA damage | metabolic process | nucleotide-excision repair | regulation of DNA-templated transcription in response to stress | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | cellular protein localization | virion assembly | amide transport | positive regulation of cell death | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | regulation of mRNA catabolic process | positive regulation of NF-kappaB transcription factor activity | positive regulation of programmed cell death | positive regulation of kinase activity | protein modification by small protein conjugation or removal | regulation of phosphate metabolic process | establishment of protein localization | positive regulation of MAPK cascade | intracellular receptor signaling pathway | ubiquitin-dependent protein catabolic process | transforming growth factor beta receptor signaling pathway | organonitrogen compound catabolic process | transcription-coupled nucleotide-excision repair | regulation of cell communication | negative regulation of signal transduction | transmembrane transport | signaling | regulation of transcription, DNA-templated | I-kappaB kinase/NF-kappaB signaling | protein localization | positive regulation of phosphorylation | cellular protein metabolic process | regulation of transcription from RNA polymerase II promoter in response to stress | cellular macromolecule localization | cellular macromolecule biosynthetic process | positive regulation of MAP kinase activity | regulation of transcription from RNA polymerase II promoter in response to hypoxia | organelle organization | cellular response to interleukin-1 | cellular protein modification process | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | DNA synthesis involved in DNA repair | MyD88-dependent toll-like receptor signaling pathway | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | protein targeting | immune system process | cellular metabolic process | cellular response to organic substance | regulation of cell death | modification-dependent protein catabolic process | negative regulation of cell death | positive regulation of signaling | signal transduction | regulation of signaling | nucleotide-excision repair, preincision complex assembly | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | endocytic vesicle membrane | host cell | organelle membrane | cytoplasmic vesicle | cell | organelle outer membrane | nuclear lumen | other organism cell | cytoplasm | intracellular organelle | endoplasmic reticulum | endosome membrane | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | nucleoplasm | plasma membrane | vesicle | extracellular exosome | mitochondrion | endosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | mitochondrial outer membrane | vesicle membrane | mitochondrial envelope | extracellular space | cell periphery | membrane-enclosed lumen | outer membrane | mitochondrial membrane | cytosol | intracellular vesicle | endocytic vesicle | intracellular | myelin sheath | membrane | cytoplasmic vesicle membrane