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QuickView for TIAM1;jsessionid=B96A9EF7831E2E1D823E729431B49C39 (gene)


Gene Symbol:
TIAM1 Homo sapiens Homo sapiens
Full name:
T cell lymphoma invasion and metastasis 1
Synonyms:
TIAM-1, T-lymphoma invasion and metastasis-inducing protein 1, human T-lymphoma invasion and metastasis inducing TIAM1 protein
Genomic Location:
Chr 21: 31412607-31853161
Description:
This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affec...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 21
21q22.11





GO Molecular Function

Rho guanyl-nucleotide exchange factor activity | guanyl-nucleotide exchange factor activity | kinase binding | GTPase binding | Rho GTPase binding | protein kinase binding | receptor tyrosine kinase binding | enzyme binding | lipid binding | signaling receptor binding | Ras GTPase binding | molecular function regulator | cytoskeletal protein binding | protein tyrosine kinase binding | protein binding | Rac GTPase binding | Ras guanyl-nucleotide exchange factor activity | small GTPase binding | microtubule binding | tubulin binding | Rac guanyl-nucleotide exchange factor activity

GO Biological Process

regulation of JUN kinase activity | regulation of ERK1 and ERK2 cascade | cell morphogenesis | Rho guanyl-nucleotide exchange factor activity | positive regulation of locomotion | activation of GTPase activity | guanyl-nucleotide exchange factor activity | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | regulation of neurogenesis | neuron projection morphogenesis | regulation of cellular localization | intracellular signal transduction | positive regulation of apoptotic process | regulation of cell development | regulation of localization | cell-substrate adhesion | regulation of programmed cell death | positive regulation of developmental process | regulation of MAP kinase activity | cell differentiation | nervous system development | response to drug | cell part morphogenesis | positive regulation of axonogenesis | NMDA selective glutamate receptor signaling pathway | neurogenesis | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | regulation of peptide hormone secretion | generation of neurons | positive regulation of dendritic spine morphogenesis | positive regulation of GTPase activity | neuron projection extension | cellular process | regulation of cell motility | regulation of dendritic spine morphogenesis | localization | cell projection morphogenesis | developmental growth | regulation of dopaminergic neuron differentiation | neuron development | positive regulation of epithelial to mesenchymal transition | positive regulation of protein kinase activity | macromolecule localization | regulation of chemotaxis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | regulation of binding | regulation of cell differentiation | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | small GTPase mediated signal transduction | positive regulation of cellular protein metabolic process | regulation of establishment of planar polarity | ephrin receptor signaling pathway | cellular component organization | positive regulation of protein binding | positive regulation of dendrite morphogenesis | regulation of peptide secretion | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | regulation of insulin secretion | positive regulation of protein metabolic process | response to cocaine | regulation of modification of synaptic structure | regulation of cell proliferation | programmed cell death | cellular localization | positive regulation of gliogenesis | regulation of protein transport | G-protein coupled receptor signaling pathway | positive regulation of protein serine/threonine kinase activity | regulation of synapse structure or activity | regulation of peptide transport | Wnt signaling pathway, planar cell polarity pathway | cell-cell signaling | molecular function regulator | cell surface receptor signaling pathway involved in cell-cell signaling | regulation of glial cell migration | regulation of cellular response to stress | locomotion | response to nitrogen compound | apoptotic process | system development | regulation of signal transduction | Wnt signaling pathway | positive regulation of neuron projection development | multicellular organism development | cell migration | regulation of MAPK cascade | regulation of axonogenesis | regulation of catalytic activity | regulation of insulin secretion involved in cellular response to glucose stimulus | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | regulation of small GTPase mediated signal transduction | regulation of neuron differentiation | positive regulation of chemotaxis | protein localization to membrane | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | response to ammonium ion | regulation of synapse organization | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | positive regulation of JNK cascade | positive regulation of cell projection organization | positive regulation of intracellular signal transduction | regulation of cellular component movement | positive regulation of hydrolase activity | positive regulation of cell differentiation | non-canonical Wnt signaling pathway | positive regulation of cell migration | regulation of Rho protein signal transduction | cardiac muscle hypertrophy | regulation of cellular protein metabolic process | regulation of GTPase activity | positive regulation of dendritic spine development | response to xenobiotic stimulus | regulation of modification of postsynaptic actin cytoskeleton | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | Rac protein signal transduction | positive regulation of Schwann cell chemotaxis | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | positive regulation of dendrite development | positive regulation of molecular function | neuron differentiation | regulation of cell morphogenesis involved in differentiation | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | regulation of kinase activity | positive regulation of Schwann cell migration | regulation of animal organ morphogenesis | regulation of intracellular signal transduction | anatomical structure development | developmental growth involved in morphogenesis | regulation of dendrite morphogenesis | cell surface receptor signaling pathway | positive regulation of neurogenesis | cell projection organization | positive regulation of cell development | regulation of Schwann cell migration | cellular protein localization | Ras guanyl-nucleotide exchange factor activity | regulation of secretion | positive regulation of cell death | cell adhesion | neuron projection development | regulation of non-canonical Wnt signaling pathway | cell death | regulation of protein secretion | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | response to alkaloid | positive regulation of binding | regulation of postsynapse organization | regulation of JNK cascade | positive regulation of MAPK cascade | positive regulation of glial cell migration | regulation of dendrite development | regulation of stress-activated MAPK cascade | regulation of cell communication | regulation of gliogenesis | regulation of dendritic spine development | signaling | cell-matrix adhesion | regulation of protein binding | response to organic cyclic compound | cell development | protein localization | positive regulation of phosphorylation | regulation of Ras protein signal transduction | anatomical structure morphogenesis | cellular macromolecule localization | positive regulation of MAP kinase activity | glutamate receptor signaling pathway | regulation of nervous system development | regulation of developmental process | developmental process | regulation of transport | developmental cell growth | Ras protein signal transduction | response to organonitrogen compound | regulation of epithelial to mesenchymal transition | positive regulation of JUN kinase activity | response to anesthetic | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | positive regulation of neuron differentiation | Rac guanyl-nucleotide exchange factor activity | regulation of cell projection organization | regulation of protein localization | regulation of cell death | positive regulation of cell motility | positive regulation of cell morphogenesis involved in differentiation | ionotropic glutamate receptor signaling pathway | muscle hypertrophy | regulation of cellular component organization | muscle system process | positive regulation of signaling | signal transduction | regulation of signaling | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

supramolecular fiber | dendritic spine | cytoplasmic side of plasma membrane | dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | extrinsic component of membrane | ruffle | somatodendritic compartment | cell projection membrane | cell body | cell | cytoplasmic side of membrane | neuronal cell body | extrinsic component of plasma membrane | distal axon | ruffle membrane | microtubule | cytoplasm | intracellular organelle | dendritic tree | leading edge membrane | main axon | cell-cell junction | cell-cell contact zone | cell projection | neuron spine | postsynapse | plasma membrane | extrinsic component of cytoplasmic side of plasma membrane | cell leading edge | postsynaptic density | microtubule cytoskeleton | asymmetric synapse | site of polarized growth | axonal growth cone | membrane-bounded organelle | nucleus | organelle | postsynaptic specialization | cell periphery | axon | growth cone | cytosol | cytoskeleton | intracellular | cell junction | membrane | supramolecular complex