Correlation Engine 2.0
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QuickView for TIARP (gene)

Gene Symbol:
STEAP4 Homo sapiens Homo sapiens
Full name:
STEAP4 metalloreductase
STAMP2, SchLAH, TIARP, TNFAIP9, metalloreductase STEAP4, STEAP family member 4, seven chromosome locus associated with HCC, six transmembrane prostate protein 2, six-transmembrane epithelial antigen of prostate 4, sixTransMembrane protein of prostate 2, tumor necrosis factor, alpha-induced protein 9, tumor necrosis-alpha-induced adipose-related protein
Genomic Location:
Chr 7: 87743680-87774145
The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved i...
Mus musculus Rattus norvegicus Macaca mulatta Pan troglodytes Canis lupus familiaris Bos taurus Gallus gallus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 7

GO Molecular Function

cation binding | oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor | oxidoreductase activity, oxidizing metal ions | catalytic activity | ferric-chelate reductase (NADPH) activity | ion binding | cupric reductase activity | metal ion binding | oxidoreductase activity

GO Biological Process

iron ion transmembrane transport | establishment of localization | cell differentiation | ferric iron import across plasma membrane | cellular process | localization | metal ion transport | transition metal ion transport | iron ion import | oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor | oxidoreductase activity, oxidizing metal ions | metal ion homeostasis | ferric-chelate reductase (NADPH) activity | ion transmembrane transport | fat cell differentiation | cation homeostasis | ferric iron transport | homeostatic process | iron ion homeostasis | cation transmembrane transport | iron ion import across plasma membrane | import into cell | copper ion import | metabolic process | oxidation-reduction process | chemical homeostasis | ferric iron import | copper ion transport | ion homeostasis | inorganic cation transmembrane transport | transmembrane transport | cation transport | iron ion transport | developmental process | inorganic cation import across plasma membrane | cupric reductase activity | ion transport | transition metal ion homeostasis | oxidoreductase activity

GO Cellular Component

intracellular membrane-bounded organelle | early endosome membrane | organelle membrane | cytoplasmic vesicle | cell | cytoplasm | intracellular organelle | endosome membrane | Golgi apparatus | endomembrane system | plasma membrane | vesicle | extracellular exosome | Golgi membrane | endosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | early endosome | intracellular vesicle | intracellular | membrane