QuickView for TIARP (gene)

Gene Symbol:

STEAP4 Homo sapiens

Full name:

STEAP4 metalloreductase

Synonyms:

STAMP2, SchLAH, TIARP, TNFAIP9, metalloreductase STEAP4, STEAP family member 4, seven chromosome locus associated with HCC, six transmembrane prostate protein 2, six-transmembrane epithelial antigen of prostate 4, sixTransMembrane protein of prostate 2, tumor necrosis factor, alpha-induced protein 9, tumor necrosis-alpha-induced adipose-related protein

Genomic Location:

Chr 7: 87743680-87774145

Description:

The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved i...

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The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Gallus gallus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PAX4_04 ,  AACTGGA_MIR145 ,  MEIS1BHOXA9_01 ,  TATAAA_TATA_01 ,  CEBPB_02 ,  YKACATTT_UNKNOWN ,  GFI1_01 ,  TGCTTTG_MIR330 ,  TTCYNRGAA_STAT5B_01 ,  RORA2_01 ,  STAT5A_01 ,  AACTTT_UNKNOWN ,  TGACATY_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-330

Cytogenetic Map:

7q21.12

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