QuickView for TID1 (gene)

Gene Symbol:

DNAJA3 Homo sapiens

Full name:

DnaJ heat shock protein family (Hsp40) member A3

Synonyms:

HCA57, TID1, hTID-1, dnaJ homolog subfamily A member 3, mitochondrial, DnaJ (Hsp40) homolog, subfamily A, member 3, dnaJ protein Tid-1, hepatocellular carcinoma-associated antigen 57, tumorous imaginal discs protein Tid56 homolog

Genomic Location:

Chr 16: 4415883-4446777

Description:

This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and ap...

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This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CAGCACT_MIR5123P ,  DBP_Q6 ,  CAGCCTC_MIR4855P ,  RCGCANGCGY_NRF1_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-485-5p ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

16p13.3

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