QuickView for TIEG2 (gene)
- Gene Symbol:
- KLF11
Homo sapiens - Full name:
- Kruppel like factor 11
- Synonyms:
- FKLF, FKLF1, MODY7, TIEG2, Tieg3, Krueppel-like factor 11, TGFB-inducible early growth response protein 2, TIEG-2, transforming growth factor-beta-inducible early growth response protein 2
- Genomic Location:
- Chr 2: 10101133-10112414
- Description:
-
The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoform...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
2p25.1
GO Molecular Function
transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cation binding | nucleic acid binding | DNA binding | ion binding | organic cyclic compound binding | protein binding | DNA-binding transcription factor activity | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | positive regulation of apoptotic process | regulation of programmed cell death | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cellular process | negative regulation of nucleic acid-templated transcription | negative regulation of cellular metabolic process | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | response to stimulus | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | response to peptide | programmed cell death | cellular nitrogen compound metabolic process | cell cycle G1/S phase transition | negative regulation of metabolic process | cellular biosynthetic process | regulation of nucleic acid-templated transcription | response to nitrogen compound | apoptotic process | nitrogen compound metabolic process | regulation of gene expression | cellular response to peptide | cell cycle | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | mitotic cell cycle phase transition | regulation of cellular metabolic process | regulation of transcription involved in G1/S transition of mitotic cell cycle | G1/S transition of mitotic cell cycle | regulation of RNA metabolic process | DNA-binding transcription factor activity | response to organic substance | mitotic cell cycle | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | positive regulation of cell death | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | positive regulation of programmed cell death | transcription, DNA-templated | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | negative regulation of transcription by RNA polymerase II | negative regulation of cell proliferation | response to organonitrogen compound | cell cycle phase transition | heterocycle metabolic process | cellular metabolic process | cellular response to organic substance | regulation of cell death | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | adherens junction | focal adhesion | cell | nuclear lumen | cytoplasm | cell-substrate junction | intracellular organelle | nuclear body | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cell-substrate adherens junction | cytosol | intracellular | cell junction
