QuickView for TIF1ALPHA (gene)
- Gene Symbol:
- TRIM24
Homo sapiens - Full name:
- tripartite motif containing 24
- Synonyms:
- PTC6, RNF82, TF1A, TIF1, TIF1A, TIF1ALPHA, hTIF1, transcription intermediary factor 1-alpha, E3 ubiquitin-protein ligase TRIM24, RING finger protein 82, RING-type E3 ubiquitin transferase TIF1-alpha, TIF1-alpha, transcriptional intermediary factor 1
- Genomic Location:
- Chr 7: 137795619-137920873
- Description:
-
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The pro...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Bos taurus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
7q33-q34
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | cation binding | hormone receptor binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | signaling receptor binding | lysine-acetylated histone binding | methylated histone binding | catalytic activity | chromatin binding | ubiquitin-like protein transferase activity | modification-dependent protein binding | RNA polymerase II regulatory region DNA binding | p53 binding | DNA binding | sequence-specific double-stranded DNA binding | ubiquitin protein ligase activity | nuclear hormone receptor binding | ion binding | organic cyclic compound binding | transcription coactivator activity | transcription regulatory region sequence-specific DNA binding | protein tyrosine kinase activity | protein binding | zinc ion binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcription factor binding | transferase activity, transferring phosphorus-containing groups | ubiquitin-protein transferase activity | estrogen response element binding | phosphotransferase activity, alcohol group as acceptor | RNA polymerase II regulatory region sequence-specific DNA binding | protein kinase activity | transferase activity | histone binding | transition metal ion binding | ubiquitin-like protein ligase activity | nuclear receptor binding | kinase activity | transcription coregulator activity | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | positive regulation of macromolecule biosynthetic process | regulation of programmed cell death | peptidyl-amino acid modification | negative regulation of cellular process | negative regulation of RNA biosynthetic process | peptidyl-tyrosine phosphorylation | positive regulation of cellular biosynthetic process | cellular process | organic substance catabolic process | negative regulation of nucleic acid-templated transcription | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | calcium ion homeostasis | response to stimulus | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | cellular nitrogen compound metabolic process | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | cellular biosynthetic process | macromolecule modification | metal ion homeostasis | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | regulation of signal transduction | regulation of protein stability | phosphorus metabolic process | regulation of gene expression | protein catabolic process | regulation of signal transduction by p53 class mediator | positive regulation of cellular metabolic process | protein autophosphorylation | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | ubiquitin protein ligase activity | biosynthetic process | aromatic compound biosynthetic process | phosphorylation | protein phosphorylation | cation homeostasis | phosphate-containing compound metabolic process | response to estrogen | regulation of cellular metabolic process | cellular response to estrogen stimulus | homeostatic process | transcription coactivator activity | regulation of RNA metabolic process | protein tyrosine kinase activity | protein metabolic process | protein ubiquitination | regulation of intracellular signal transduction | metabolic process | ubiquitin-protein transferase activity | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | chemical homeostasis | nucleobase-containing compound metabolic process | protein kinase activity | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | ion homeostasis | protein modification by small protein conjugation or removal | transcription, DNA-templated | regulation of vitamin D receptor signaling pathway | organonitrogen compound catabolic process | regulation of cell communication | regulation of transcription, DNA-templated | cellular protein metabolic process | cellular macromolecule biosynthetic process | kinase activity | cellular protein modification process | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | regulation of cell death | divalent inorganic cation homeostasis | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process
GO Cellular Component
nuclear euchromatin | chromosome | intracellular membrane-bounded organelle | perichromatin fibrils | cell | nuclear lumen | cytoplasm | intracellular organelle | euchromatin | nucleoplasm | chromatin | nuclear chromosome | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | cytosol | intracellular
