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QuickView for TIMP3 (gene)


Gene Symbol:
TIMP3 Homo sapiens Homo sapiens
Full name:
TIMP metallopeptidase inhibitor 3
Synonyms:
HSMRK222, K222, K222TA2, SFD, metalloproteinase inhibitor 3, MIG-5 protein, TIMP-3, protein MIG-5, tissue inhibitor of metalloproteinases 3
Genomic Location:
Chr 22: 31526802-31589028
Description:
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the EC...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 22
22q12.3


Transcripts Names
NM_000362
Protein Names
Q9UC74
B2RBY9
Q9UGS2
P35625
Q5THV4



GO Molecular Function

endopeptidase inhibitor activity | cation binding | enzyme binding | enzyme inhibitor activity | molecular function regulator | ion binding | protein binding | metalloendopeptidase inhibitor activity | peptidase inhibitor activity | enzyme regulator activity | protease binding | metal ion binding

GO Biological Process

negative regulation of metalloendopeptidase activity | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | negative regulation of membrane protein ectodomain proteolysis | endopeptidase inhibitor activity | negative regulation of MAPK cascade | exocytosis | response to cytokine | positive regulation of apoptotic process | regulation of programmed cell death | establishment of localization | response to hormone | platelet degranulation | negative regulation of cellular process | negative regulation of protein phosphorylation | negative regulation of proteolysis | cellular process | secretion | localization | negative regulation of signaling | regulation of proteolysis | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors | negative regulation of cellular metabolic process | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | response to stimulus | enzyme inhibitor activity | secretion by cell | negative regulation of metabolic process | negative regulation of ERK1 and ERK2 cascade | molecular function regulator | regulation of signal transduction | negative regulation of phosphate metabolic process | negative regulation of catalytic activity | regulation of peptidase activity | regulation of MAPK cascade | regulation of catalytic activity | regulation of phosphorylation | negative regulation of peptidase activity | regulation of extrinsic apoptotic signaling pathway | nervous system process | negative regulation of metallopeptidase activity | regulation of nitrogen compound metabolic process | vesicle-mediated transport | regulation of cellular protein metabolic process | regulated exocytosis | regulation of apoptotic signaling pathway | positive regulation of extrinsic apoptotic signaling pathway | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | response to organic substance | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | visual perception | regulation of protein catabolic process | positive regulation of cell death | sensory perception of light stimulus | negative regulation of cellular protein metabolic process | positive regulation of programmed cell death | regulation of phosphate metabolic process | positive regulation of TRAIL-activated apoptotic signaling pathway | negative regulation of protein catabolic process | negative regulation of protein metabolic process | sensory perception | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | regulation of extrinsic apoptotic signaling pathway via death domain receptors | metalloendopeptidase inhibitor activity | peptidase inhibitor activity | enzyme regulator activity | regulation of endopeptidase activity | negative regulation of hydrolase activity | cellular response to organic substance | regulation of cell death | positive regulation of apoptotic signaling pathway | positive regulation of signaling | regulation of signaling | negative regulation of endopeptidase activity | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | intracellular membrane-bounded organelle | extracellular matrix | basement membrane | cytoplasmic vesicle | cell | platelet dense granule | cytoplasmic vesicle lumen | cytoplasm | collagen-containing extracellular matrix | intracellular organelle | platelet dense granule lumen | secretory vesicle | endomembrane system | vesicle | extracellular region | membrane-bounded organelle | nucleus | organelle | extracellular space | membrane-enclosed lumen | secretory granule lumen | intracellular vesicle | intracellular | vesicle lumen