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QuickView for TINF2 (gene)


Gene Symbol:
TINF2 Homo sapiens Homo sapiens
Full name:
TERF1 interacting nuclear factor 2
Synonyms:
DKCA3, TIN2, TERF1-interacting nuclear factor 2, TERF1 (TRF1)-interacting nuclear factor 2, TRF1-interacting nuclear protein 2
Genomic Location:
Chr 14: 23778689-23781720
Description:
This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for as...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Pan troglodytes Bos taurus Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 14
14q12





GO Molecular Function

sequence-specific DNA binding | nucleic acid binding | DNA binding | organic cyclic compound binding | protein binding | heterocyclic compound binding | telomeric DNA binding

GO Biological Process

regulation of telomere maintenance via telomerase | telomere maintenance | negative regulation of cellular process | telomere capping | regulation of organelle organization | negative regulation of DNA metabolic process | cellular process | negative regulation of DNA biosynthetic process | localization | macromolecule localization | negative regulation of cellular metabolic process | anatomical structure homeostasis | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | regulation of cell proliferation | cellular localization | cellular nitrogen compound metabolic process | telomere organization | negative regulation of metabolic process | cellular component assembly | nitrogen compound metabolic process | regulation of telomere maintenance | regulation of nitrogen compound metabolic process | protein localization to organelle | regulation of cellular protein metabolic process | regulation of telomere maintenance via telomere lengthening | regulation of cellular metabolic process | regulation of protein metabolic process | homeostatic process | negative regulation of telomere maintenance | negative regulation of epithelial cell proliferation | protein localization to chromosome, telomeric region | DNA metabolic process | metabolic process | cellular protein localization | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | telomere assembly | negative regulation of cellular protein metabolic process | negative regulation of telomere maintenance via telomerase | regulation of chromosome organization | regulation of protein ADP-ribosylation | negative regulation of protein metabolic process | negative regulation of chromosome organization | negative regulation of telomere maintenance via telomere lengthening | protein localization | regulation of epithelial cell proliferation | cellular macromolecule localization | organelle organization | regulation of DNA biosynthetic process | negative regulation of cell proliferation | heterocycle metabolic process | chromosome organization | cellular metabolic process | negative regulation of protein ADP-ribosylation | regulation of cellular component organization | protein localization to chromosome | macromolecule metabolic process

GO Cellular Component

shelterin complex | nuclear telomere cap complex | chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | perinucleolar chromocenter | intracellular organelle | nuclear body | chromocenter | protein-containing complex | protein-DNA complex | telomere cap complex | nucleoplasm | nuclear chromosome | chromosome, telomeric region | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear matrix | nuclear chromosome, telomeric region | intracellular | nuclear periphery