QuickView for TIP120 (gene)

Gene Symbol:

CAND1 Homo sapiens

Full name:

cullin associated and neddylation dissociated 1

Synonyms:

TIP120, TIP120A, cullin-associated NEDD8-dissociated protein 1, TBP-interacting protein of 120 kDa A, p120 CAND1

Genomic Location:

Chr 12: 65949416-65994189

Description:

This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex asse...

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This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  E2F4DP1_01 ,  NGFIC_01 ,  TMTCGCGANR_UNKNOWN ,  TTTGTAG_MIR520D ,  E2F_Q6 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  EGR_Q6 ,  E2F_Q4 ,  GGGCGGR_SP1_Q6 ,  ATGTTAA_MIR302C ,  E2F1DP2_01 ,  AP2_Q3 ,  E2F_03 ,  E2F1DP1_01 ,  GFI1_01 ,  E2F1DP1RB_01 ,  E2F_02 ,  E2F1_Q3 ,  E2F4DP2_01 ,  EGR1_01 ,  TATTATA_MIR374 ,  E2F1_Q6 ,  SGCGSSAAA_E2F1DP2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-134 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-543

miRNA binding sites
(Source: miRecords):

hsa-miR-1 Targeted Genes

Cytogenetic Map:

12q14.3-q15

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